Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1972864..1973324 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag BCG_RS09195 Protein ID WP_003408531.1
Coordinates 1973076..1973324 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag BCG_RS09190 Protein ID WP_003408528.1
Coordinates 1972864..1973076 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS09175 1969342..1970529 - 1188 WP_003898992.1 nitrate transporter NarK -
BCG_RS09180 1970816..1971100 + 285 WP_003408522.1 DUF1876 domain-containing protein -
BCG_RS09185 1971114..1972796 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
BCG_RS09190 1972864..1973076 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCG_RS09195 1973076..1973324 + 249 WP_003408531.1 hypothetical protein Toxin
BCG_RS09200 1973332..1974070 + 739 Protein_1796 hypothetical protein -
BCG_RS09205 1974164..1975864 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
BCG_RS09210 1976149..1976550 - 402 WP_010950586.1 hypothetical protein -
BCG_RS09215 1976621..1977151 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T21873 WP_003408531.1 NC_008769:1973076-1973324 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T21873 NC_008769:1973076-1973324 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT21873 WP_003408528.1 NC_008769:1972864-1973076 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT21873 NC_008769:1972864-1973076 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References