Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 810471..811128 Replicon chromosome
Accession NZ_CP084502
Organism Klebsiella pneumoniae strain MI01_K

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KRU50_RS04010 Protein ID WP_002916310.1
Coordinates 810718..811128 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KRU50_RS04005 Protein ID WP_002916312.1
Coordinates 810471..810737 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KRU50_RS03980 (805627) 805627..807060 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KRU50_RS03985 (807179) 807179..807907 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KRU50_RS03990 (807957) 807957..808268 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KRU50_RS03995 (808432) 808432..809091 + 660 WP_002916317.1 hemolysin III family protein -
KRU50_RS04000 (809242) 809242..810225 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
KRU50_RS04005 (810471) 810471..810737 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KRU50_RS04010 (810718) 810718..811128 + 411 WP_002916310.1 protein YgfX Toxin
KRU50_RS04015 (811135) 811135..811656 - 522 WP_004144730.1 flavodoxin FldB -
KRU50_RS04020 (811757) 811757..812653 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KRU50_RS04025 (812676) 812676..813389 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KRU50_RS04030 (813395) 813395..815128 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T218724 WP_002916310.1 NZ_CP084502:810718-811128 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T218724 NZ_CP116088:c751084-750908 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT218724 WP_002916312.1 NZ_CP084502:810471-810737 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218724 NZ_CP116088:c750862-750446 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References