218716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 116758..117401 Replicon plasmid p1632-1
Accession NZ_CP084498
Organism Klebsiella pneumoniae strain 1632

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag LDL62_RS27980 Protein ID WP_001044770.1
Coordinates 116758..117174 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag LDL62_RS27985 Protein ID WP_001261282.1
Coordinates 117171..117401 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL62_RS27960 (112861) 112861..113133 - 273 Protein_158 transposase -
LDL62_RS27970 (114115) 114115..115137 - 1023 WP_000361404.1 helicase UvrD -
LDL62_RS27975 (115122) 115122..116684 - 1563 WP_004206609.1 AAA family ATPase -
LDL62_RS27980 (116758) 116758..117174 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
LDL62_RS27985 (117171) 117171..117401 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LDL62_RS27990 (117358) 117358..117819 + 462 WP_014343465.1 hypothetical protein -
LDL62_RS27995 (117980) 117980..118924 + 945 WP_011977810.1 hypothetical protein -
LDL62_RS28000 (118961) 118961..119353 + 393 WP_011977811.1 hypothetical protein -
LDL62_RS28005 (119411) 119411..119932 + 522 WP_013214008.1 hypothetical protein -
LDL62_RS28010 (119978) 119978..120181 + 204 WP_011977813.1 hypothetical protein -
LDL62_RS28015 (120211) 120211..121215 + 1005 WP_011977814.1 hypothetical protein -
LDL62_RS28020 (121399) 121399..122178 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 - 1..163933 163933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T218716 WP_001044770.1 NZ_CP084498:c117174-116758 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T218716 NZ_CP116085:c4262725-4262348 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT218716 WP_001261282.1 NZ_CP084498:c117401-117171 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT218716 NZ_CP116085:c4263182-4262814 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTTTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References