218710

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4919205..4919721 Replicon chromosome
Accession NZ_CP084497
Organism Klebsiella pneumoniae strain 1632

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LDL62_RS24470 Protein ID WP_002886902.1
Coordinates 4919205..4919489 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LDL62_RS24475 Protein ID WP_002886901.1
Coordinates 4919479..4919721 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL62_RS24445 (LDL62_24445) 4914689..4914952 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LDL62_RS24450 (LDL62_24450) 4915082..4915255 + 174 WP_002886906.1 hypothetical protein -
LDL62_RS24455 (LDL62_24455) 4915258..4916001 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LDL62_RS24460 (LDL62_24460) 4916358..4918496 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LDL62_RS24465 (LDL62_24465) 4918737..4919201 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDL62_RS24470 (LDL62_24470) 4919205..4919489 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDL62_RS24475 (LDL62_24475) 4919479..4919721 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDL62_RS24480 (LDL62_24480) 4919799..4921709 - 1911 WP_004152270.1 PRD domain-containing protein -
LDL62_RS24485 (LDL62_24485) 4921732..4922886 - 1155 WP_002886900.1 lactonase family protein -
LDL62_RS24490 (LDL62_24490) 4922952..4923692 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T218710 WP_002886902.1 NZ_CP084497:c4919489-4919205 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218710 NZ_CP116085:2777103-2777210 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218710 WP_002886901.1 NZ_CP084497:c4919721-4919479 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218710 NZ_CP116085:c2777046-2776991 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References