218708

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4203222..4203841 Replicon chromosome
Accession NZ_CP084497
Organism Klebsiella pneumoniae strain 1632

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LDL62_RS21040 Protein ID WP_002892050.1
Coordinates 4203623..4203841 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LDL62_RS21035 Protein ID WP_002892066.1
Coordinates 4203222..4203596 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL62_RS21025 (LDL62_21025) 4198374..4199567 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDL62_RS21030 (LDL62_21030) 4199590..4202736 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LDL62_RS21035 (LDL62_21035) 4203222..4203596 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LDL62_RS21040 (LDL62_21040) 4203623..4203841 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LDL62_RS21045 (LDL62_21045) 4204000..4204566 + 567 WP_002892030.1 maltose O-acetyltransferase -
LDL62_RS21050 (LDL62_21050) 4204538..4204678 - 141 WP_004147370.1 hypothetical protein -
LDL62_RS21055 (LDL62_21055) 4204699..4205169 + 471 WP_002892026.1 YlaC family protein -
LDL62_RS21060 (LDL62_21060) 4205144..4206595 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LDL62_RS21065 (LDL62_21065) 4206696..4207394 + 699 WP_002892021.1 GNAT family protein -
LDL62_RS21070 (LDL62_21070) 4207391..4207531 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LDL62_RS21075 (LDL62_21075) 4207531..4207794 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218708 WP_002892050.1 NZ_CP084497:4203623-4203841 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T218708 NZ_CP116085:2240205-2240307 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT218708 WP_002892066.1 NZ_CP084497:4203222-4203596 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT218708 NZ_CP116085:c2240345-2240077 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References