Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877237..877891 Replicon chromosome
Accession NZ_CP084497
Organism Klebsiella pneumoniae strain 1632

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LDL62_RS04435 Protein ID WP_004144731.1
Coordinates 877484..877891 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LDL62_RS04430 Protein ID WP_002916312.1
Coordinates 877237..877503 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL62_RS04405 (LDL62_04405) 872393..873826 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LDL62_RS04410 (LDL62_04410) 873945..874673 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LDL62_RS04415 (LDL62_04415) 874723..875034 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LDL62_RS04420 (LDL62_04420) 875198..875857 + 660 WP_002916317.1 hemolysin III family protein -
LDL62_RS04425 (LDL62_04425) 876008..876991 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LDL62_RS04430 (LDL62_04430) 877237..877503 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LDL62_RS04435 (LDL62_04435) 877484..877891 + 408 WP_004144731.1 protein YgfX Toxin
LDL62_RS04440 (LDL62_04440) 877898..878419 - 522 WP_002916308.1 flavodoxin FldB -
LDL62_RS04445 (LDL62_04445) 878520..879416 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LDL62_RS04450 (LDL62_04450) 879439..880152 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDL62_RS04455 (LDL62_04455) 880158..881891 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T218698 WP_004144731.1 NZ_CP084497:877484-877891 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T218698 NZ_CP116085:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT218698 WP_002916312.1 NZ_CP084497:877237-877503 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218698 NZ_CP116085:c188484-188426 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References