218694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1706..2286 Replicon plasmid p1864-4
Accession NZ_CP084496
Organism Klebsiella pneumoniae strain 1864

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag LDL64_RS29600 Protein ID WP_071177730.1
Coordinates 1972..2286 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag LDL64_RS29595 Protein ID WP_000093040.1
Coordinates 1706..1984 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL64_RS29580 (LDL64_29580) 279..524 + 246 WP_032440458.1 hypothetical protein -
LDL64_RS29585 (LDL64_29585) 798..1169 + 372 WP_001237044.1 cell envelope integrity protein TolA -
LDL64_RS29590 (LDL64_29590) 1166..1531 + 366 WP_072354022.1 TonB family protein -
LDL64_RS29595 (LDL64_29595) 1706..1984 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
LDL64_RS29600 (LDL64_29600) 1972..2286 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDL64_RS29605 (LDL64_29605) 2450..2878 + 429 WP_001140599.1 hypothetical protein -
LDL64_RS29610 (LDL64_29610) 2904..3083 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
LDL64_RS29615 (LDL64_29615) 3110..3640 - 531 WP_071177729.1 hypothetical protein -
LDL64_RS29620 (LDL64_29620) 3647..4378 - 732 WP_071177728.1 MobC family replication-relaxation protein -
LDL64_RS29625 (LDL64_29625) 4378..6342 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T218694 WP_071177730.1 NZ_CP084496:1972-2286 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T218694 NZ_CP116077:70131-70280 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT218694 WP_000093040.1 NZ_CP084496:1706-1984 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT218694 NZ_CP116077:c70086-70027 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References