Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 8686..9596 | Replicon | plasmid p1864-1 |
Accession | NZ_CP084493 | ||
Organism | Klebsiella pneumoniae strain 1864 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | LDL64_RS26670 | Protein ID | WP_004026354.1 |
Coordinates | 9126..9596 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A2J4RLY9 |
Locus tag | LDL64_RS26665 | Protein ID | WP_004181895.1 |
Coordinates | 8686..9129 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LDL64_RS26640 (LDL64_26640) | 3723..3929 | + | 207 | WP_004026437.1 | hypothetical protein | - |
LDL64_RS26645 (LDL64_26645) | 4013..4492 | + | 480 | WP_004181843.1 | hypothetical protein | - |
LDL64_RS26650 (LDL64_26650) | 5319..6806 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
LDL64_RS26655 (LDL64_26655) | 6892..7314 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
LDL64_RS26660 (LDL64_26660) | 7314..8585 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
LDL64_RS26665 (LDL64_26665) | 8686..9129 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
LDL64_RS26670 (LDL64_26670) | 9126..9596 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
LDL64_RS26675 (LDL64_26675) | 9706..9966 | - | 261 | WP_004026352.1 | hypothetical protein | - |
LDL64_RS26680 (LDL64_26680) | 10537..11718 | - | 1182 | WP_078207741.1 | IS481 family transposase | - |
LDL64_RS26685 (LDL64_26685) | 11819..12523 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
LDL64_RS26690 (LDL64_26690) | 12588..13760 | - | 1173 | Protein_12 | transposase | - |
LDL64_RS26695 (LDL64_26695) | 13835..14503 | - | 669 | WP_001300294.1 | EAL domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaTEM-1B / aac(3)-IId / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..296908 | 296908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T218684 WP_004026354.1 NZ_CP084493:9126-9596 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T218684 NZ_CP116074:2777399-2777506 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT218684 WP_004181895.1 NZ_CP084493:8686-9129 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT218684 NZ_CP116074:c2777349-2777286 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4RLY9 |