Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4817851..4818367 Replicon chromosome
Accession NZ_CP084492
Organism Klebsiella pneumoniae strain 1864

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LDL64_RS23940 Protein ID WP_002886902.1
Coordinates 4817851..4818135 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LDL64_RS23945 Protein ID WP_002886901.1
Coordinates 4818125..4818367 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL64_RS23915 (LDL64_23915) 4813335..4813598 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LDL64_RS23920 (LDL64_23920) 4813728..4813901 + 174 WP_002886906.1 hypothetical protein -
LDL64_RS23925 (LDL64_23925) 4813904..4814647 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LDL64_RS23930 (LDL64_23930) 4815004..4817142 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LDL64_RS23935 (LDL64_23935) 4817383..4817847 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDL64_RS23940 (LDL64_23940) 4817851..4818135 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDL64_RS23945 (LDL64_23945) 4818125..4818367 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDL64_RS23950 (LDL64_23950) 4818445..4819128 - 684 Protein_4699 PTS sugar transporter subunit IIA -
LDL64_RS23960 (LDL64_23960) 4820429..4821661 - 1233 Protein_4701 transcription antiterminator -
LDL64_RS23965 (LDL64_23965) 4821684..4822838 - 1155 WP_002886900.1 lactonase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T218681 WP_002886902.1 NZ_CP084492:c4818135-4817851 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218681 NZ_CP116074:2551022-2551300 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCATCGACTTGCTGTGATTGATGCGGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218681 WP_002886901.1 NZ_CP084492:c4818367-4818125 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218681 NZ_CP116074:2551300-2551584 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References