Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4100604..4101223 | Replicon | chromosome |
Accession | NZ_CP084492 | ||
Organism | Klebsiella pneumoniae strain 1864 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | LDL64_RS20505 | Protein ID | WP_002892050.1 |
Coordinates | 4101005..4101223 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | LDL64_RS20500 | Protein ID | WP_002892066.1 |
Coordinates | 4100604..4100978 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LDL64_RS20490 (LDL64_20490) | 4095756..4096949 | + | 1194 | WP_226034492.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LDL64_RS20495 (LDL64_20495) | 4096972..4100118 | + | 3147 | WP_020326861.1 | multidrug efflux RND transporter permease subunit AcrB | - |
LDL64_RS20500 (LDL64_20500) | 4100604..4100978 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
LDL64_RS20505 (LDL64_20505) | 4101005..4101223 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
LDL64_RS20510 (LDL64_20510) | 4101382..4101948 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
LDL64_RS20515 (LDL64_20515) | 4101920..4102060 | - | 141 | WP_004147370.1 | hypothetical protein | - |
LDL64_RS20520 (LDL64_20520) | 4102081..4102551 | + | 471 | WP_002892026.1 | YlaC family protein | - |
LDL64_RS20525 (LDL64_20525) | 4102526..4103977 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
LDL64_RS20530 (LDL64_20530) | 4104078..4104776 | + | 699 | WP_002892021.1 | GNAT family protein | - |
LDL64_RS20535 (LDL64_20535) | 4104773..4104913 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
LDL64_RS20540 (LDL64_20540) | 4104913..4105176 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T218679 WP_002892050.1 NZ_CP084492:4101005-4101223 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T218679 NZ_CP116074:2144718-2144821 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT218679 WP_002892066.1 NZ_CP084492:4100604-4100978 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT218679 NZ_CP116074:c2144859-2144588 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |