Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4100604..4101223 Replicon chromosome
Accession NZ_CP084492
Organism Klebsiella pneumoniae strain 1864

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LDL64_RS20505 Protein ID WP_002892050.1
Coordinates 4101005..4101223 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LDL64_RS20500 Protein ID WP_002892066.1
Coordinates 4100604..4100978 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL64_RS20490 (LDL64_20490) 4095756..4096949 + 1194 WP_226034492.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDL64_RS20495 (LDL64_20495) 4096972..4100118 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
LDL64_RS20500 (LDL64_20500) 4100604..4100978 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LDL64_RS20505 (LDL64_20505) 4101005..4101223 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LDL64_RS20510 (LDL64_20510) 4101382..4101948 + 567 WP_002892030.1 maltose O-acetyltransferase -
LDL64_RS20515 (LDL64_20515) 4101920..4102060 - 141 WP_004147370.1 hypothetical protein -
LDL64_RS20520 (LDL64_20520) 4102081..4102551 + 471 WP_002892026.1 YlaC family protein -
LDL64_RS20525 (LDL64_20525) 4102526..4103977 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LDL64_RS20530 (LDL64_20530) 4104078..4104776 + 699 WP_002892021.1 GNAT family protein -
LDL64_RS20535 (LDL64_20535) 4104773..4104913 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LDL64_RS20540 (LDL64_20540) 4104913..4105176 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T218679 WP_002892050.1 NZ_CP084492:4101005-4101223 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T218679 NZ_CP116074:2144718-2144821 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT218679 WP_002892066.1 NZ_CP084492:4100604-4100978 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT218679 NZ_CP116074:c2144859-2144588 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References