Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878702..879356 Replicon chromosome
Accession NZ_CP084492
Organism Klebsiella pneumoniae strain 1864

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LDL64_RS04450 Protein ID WP_004144731.1
Coordinates 878949..879356 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LDL64_RS04445 Protein ID WP_002916312.1
Coordinates 878702..878968 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDL64_RS04420 (LDL64_04420) 873858..875291 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LDL64_RS04425 (LDL64_04425) 875410..876138 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LDL64_RS04430 (LDL64_04430) 876188..876499 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LDL64_RS04435 (LDL64_04435) 876663..877322 + 660 WP_002916317.1 hemolysin III family protein -
LDL64_RS04440 (LDL64_04440) 877473..878456 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LDL64_RS04445 (LDL64_04445) 878702..878968 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LDL64_RS04450 (LDL64_04450) 878949..879356 + 408 WP_004144731.1 protein YgfX Toxin
LDL64_RS04455 (LDL64_04455) 879363..879884 - 522 WP_002916308.1 flavodoxin FldB -
LDL64_RS04460 (LDL64_04460) 879985..880881 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LDL64_RS04465 (LDL64_04465) 880904..881617 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDL64_RS04470 (LDL64_04470) 881623..883356 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T218669 WP_004144731.1 NZ_CP084492:878949-879356 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T218669 NZ_CP116072:c53487-53338 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT218669 WP_002916312.1 NZ_CP084492:878702-878968 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218669 NZ_CP116072:53531-53592 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References