Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2557362..2558583 Replicon chromosome
Accession NZ_CP084484
Organism Pseudomonas sp. PS1(2021)

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LE197_RS12110 Protein ID WP_003114949.1
Coordinates 2558005..2558583 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LE197_RS12105 Protein ID WP_003088112.1
Coordinates 2557362..2557916 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE197_RS12080 (LE197_12080) 2552930..2553481 + 552 WP_003102727.1 XRE family transcriptional regulator -
LE197_RS12085 (LE197_12085) 2553478..2553876 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LE197_RS12090 (LE197_12090) 2553889..2554212 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LE197_RS12095 (LE197_12095) 2554543..2555004 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LE197_RS12100 (LE197_12100) 2555009..2557204 + 2196 WP_023108900.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LE197_RS12105 (LE197_12105) 2557362..2557916 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LE197_RS12110 (LE197_12110) 2558005..2558583 + 579 WP_003114949.1 HD domain-containing protein Toxin
LE197_RS12115 (LE197_12115) 2558691..2559878 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LE197_RS12120 (LE197_12120) 2559868..2562039 - 2172 WP_226034050.1 type I secretion system permease/ATPase -
LE197_RS12125 (LE197_12125) 2562029..2563306 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T218657 WP_003114949.1 NZ_CP084484:2558005-2558583 [Pseudomonas sp. PS1(2021)]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T218657 NZ_CP116071:2602008-2602286 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT218657 WP_003088112.1 NZ_CP084484:2557362-2557916 [Pseudomonas sp. PS1(2021)]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT218657 NZ_CP116071:2602286-2602570 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References