218654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1886983..1887518 Replicon chromosome
Accession NZ_CP084480
Organism Staphylococcus lugdunensis strain RMLUG1

Toxin (Protein)


Gene name TscT Uniprot ID C5QLS6
Locus tag LFR23_RS08975 Protein ID WP_002445368.1
Coordinates 1887195..1887518 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID C5QLS5
Locus tag LFR23_RS08970 Protein ID WP_001058489.1
Coordinates 1886983..1887192 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LFR23_RS08935 (LFR23_08930) 1882239..1882523 + 285 WP_002461410.1 co-chaperone GroES -
LFR23_RS08940 (LFR23_08935) 1882583..1884205 + 1623 WP_002461409.1 chaperonin GroEL -
LFR23_RS08945 (LFR23_08940) 1884274..1885446 - 1173 WP_002492309.1 tyrosine-type recombinase/integrase -
LFR23_RS08950 (LFR23_08945) 1885460..1886134 - 675 WP_002445345.1 helix-turn-helix transcriptional regulator -
LFR23_RS08955 (LFR23_08950) 1886307..1886525 + 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
LFR23_RS08960 (LFR23_08955) 1886530..1886847 + 318 WP_002445364.1 helix-turn-helix domain-containing protein -
LFR23_RS08965 (LFR23_08960) 1886844..1886990 + 147 WP_002445365.1 hypothetical protein -
LFR23_RS08970 (LFR23_08965) 1886983..1887192 + 210 WP_001058489.1 hypothetical protein Antitoxin
LFR23_RS08975 (LFR23_08970) 1887195..1887518 + 324 WP_002445368.1 DUF1474 family protein Toxin
LFR23_RS08980 (LFR23_08975) 1887582..1888451 + 870 WP_002445370.1 primase alpha helix C-terminal domain-containing protein -
LFR23_RS08985 (LFR23_08980) 1888465..1890174 + 1710 WP_002445371.1 DUF927 domain-containing protein -
LFR23_RS08990 (LFR23_08985) 1890522..1890887 + 366 WP_002445372.1 hypothetical protein -
LFR23_RS08995 (LFR23_08990) 1890901..1891542 + 642 WP_002492310.1 pathogenicity island protein -
LFR23_RS09000 (LFR23_08995) 1891830..1892174 + 345 WP_094449183.1 pathogenicity island protein -
LFR23_RS09005 (LFR23_09000) 1892188..1892421 + 234 WP_002492317.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 1882239..1901122 18883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 13107.51 Da        Isoelectric Point: 4.8571

>T218654 WP_002445368.1 NZ_CP084480:1887195-1887518 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE

Download         Length: 324 bp

>T218654 NZ_CP116071:2047948-2048103 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8225.24 Da        Isoelectric Point: 4.2820

>AT218654 WP_001058489.1 NZ_CP084480:1886983-1887192 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT218654 NZ_CP116071:c2047936-2047878 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A853V601

References