218648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1823932..1824450 Replicon chromosome
Accession NZ_CP084444
Organism Staphylococcus lugdunensis strain RMLUG6

Toxin (Protein)


Gene name TsdT Uniprot ID A0A853V532
Locus tag LE189_RS08655 Protein ID WP_002492077.1
Coordinates 1824238..1824450 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag LE189_RS08650 Protein ID WP_002492098.1
Coordinates 1823932..1824225 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE189_RS08630 (LE189_08625) 1819532..1820170 + 639 WP_002492090.1 thiamine phosphate synthase -
LE189_RS08635 (LE189_08630) 1820260..1821135 + 876 WP_002461212.1 membrane protein insertase YidC -
LE189_RS08640 (LE189_08635) 1821519..1822160 - 642 WP_002492092.1 HD domain-containing protein -
LE189_RS08645 (LE189_08640) 1822282..1823766 - 1485 WP_002478972.1 cardiolipin synthase -
LE189_RS08650 (LE189_08645) 1823932..1824225 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
LE189_RS08655 (LE189_08650) 1824238..1824450 + 213 WP_002492077.1 heavy metal-associated domain-containing protein Toxin
LE189_RS08660 (LE189_08655) 1824541..1824678 + 138 WP_002461206.1 Lmo0850 family protein -
LE189_RS08665 (LE189_08660) 1825092..1826282 - 1191 WP_002461205.1 FtsW/RodA/SpoVE family cell cycle protein -
LE189_RS08670 (LE189_08665) 1826638..1827708 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
LE189_RS08675 (LE189_08670) 1827726..1829084 + 1359 WP_002492089.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8087.02 Da        Isoelectric Point: 3.9947

>T218648 WP_002492077.1 NZ_CP084444:1824238-1824450 [Staphylococcus lugdunensis]
VEKRLIYITNVTNEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETSTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T218648 NZ_CP116071:885753-886160 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT218648 WP_002492098.1 NZ_CP084444:1823932-1824225 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT218648 NZ_CP116071:885506-885772 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V532

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References