Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1807378..1807896 Replicon chromosome
Accession NZ_CP084443
Organism Staphylococcus lugdunensis strain RMLUG5

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag LE167_RS08745 Protein ID WP_002478973.1
Coordinates 1807378..1807590 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag LE167_RS08750 Protein ID WP_002492098.1
Coordinates 1807603..1807896 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE167_RS08725 (LE167_08750) 1802743..1804101 - 1359 WP_002478974.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LE167_RS08730 (LE167_08755) 1804119..1805189 - 1071 WP_002461204.1 D-alanine--D-alanine ligase -
LE167_RS08735 (LE167_08760) 1805545..1806735 + 1191 WP_002461205.1 FtsW/RodA/SpoVE family cell cycle protein -
LE167_RS08740 (LE167_08765) 1807150..1807287 - 138 WP_012990785.1 Lmo0850 family protein -
LE167_RS08745 (LE167_08770) 1807378..1807590 - 213 WP_002478973.1 heavy metal-associated domain-containing protein Toxin
LE167_RS08750 (LE167_08775) 1807603..1807896 - 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
LE167_RS08755 (LE167_08780) 1808062..1809546 + 1485 WP_002478972.1 cardiolipin synthase -
LE167_RS08760 (LE167_08785) 1809668..1810309 + 642 WP_002478971.1 HD domain-containing protein -
LE167_RS08765 (LE167_08790) 1810693..1811568 - 876 WP_002461212.1 membrane protein insertase YidC -
LE167_RS08770 (LE167_08795) 1811658..1812296 - 639 WP_002478970.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8070.03 Da        Isoelectric Point: 3.9947

>T218647 WP_002478973.1 NZ_CP084443:c1807590-1807378 [Staphylococcus lugdunensis]
VEKRLIYITNVTSEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

>T218647 NZ_CP116071:178593-178700 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT218647 WP_002492098.1 NZ_CP084443:c1807896-1807603 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp

>AT218647 NZ_CP116071:c178536-178479 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References