Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1795977..1796494 Replicon chromosome
Accession NZ_CP084443
Organism Staphylococcus lugdunensis strain RMLUG5

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag LE167_RS08685 Protein ID WP_002461192.1
Coordinates 1795977..1796327 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag LE167_RS08690 Protein ID WP_002461193.1
Coordinates 1796324..1796494 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE167_RS08665 (LE167_08690) 1792899..1793669 - 771 WP_002461188.1 RNA polymerase sigma factor SigB -
LE167_RS08670 (LE167_08695) 1793644..1794123 - 480 WP_012990787.1 anti-sigma B factor RsbW -
LE167_RS08675 (LE167_08700) 1794125..1794451 - 327 WP_002461190.1 anti-sigma factor antagonist -
LE167_RS08680 (LE167_08705) 1794542..1795543 - 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
LE167_RS08685 (LE167_08710) 1795977..1796327 - 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LE167_RS08690 (LE167_08715) 1796324..1796494 - 171 WP_002461193.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LE167_RS08695 (LE167_08720) 1796581..1797729 - 1149 WP_012990786.1 alanine racemase -
LE167_RS08700 (LE167_08725) 1797777..1798169 - 393 WP_002461196.1 holo-ACP synthase -
LE167_RS08705 (LE167_08730) 1798181..1798693 - 513 WP_002478976.1 PH domain-containing protein -
LE167_RS08710 (LE167_08735) 1798680..1800194 - 1515 WP_002461198.1 PH domain-containing protein -
LE167_RS08715 (LE167_08740) 1800187..1800669 - 483 WP_002478975.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T218646 WP_002461192.1 NZ_CP084443:c1796327-1795977 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T218646 NZ_CP116071:178110-178217 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT218646 WP_002461193.1 NZ_CP084443:c1796494-1796324 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT218646 NZ_CP116071:c178062-177996 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References