Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1655704..1656513 Replicon chromosome
Accession NZ_CP084443
Organism Staphylococcus lugdunensis strain RMLUG5

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag LE167_RS07890 Protein ID WP_002458758.1
Coordinates 1655704..1655874 (-) Length 57 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A853V5R2
Locus tag LE167_RS07895 Protein ID WP_002458757.1
Coordinates 1655914..1656513 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE167_RS07865 (LE167_07890) 1650796..1651419 - 624 WP_002477980.1 response regulator transcription factor -
LE167_RS07870 (LE167_07895) 1651441..1652553 - 1113 WP_002477979.1 GAF domain-containing sensor histidine kinase -
LE167_RS07875 (LE167_07900) 1652721..1653557 + 837 WP_002477978.1 RluA family pseudouridine synthase -
LE167_RS07880 (LE167_07905) 1653622..1655007 - 1386 WP_002477977.1 class II fumarate hydratase -
LE167_RS07885 (LE167_07910) 1655135..1655530 - 396 WP_002458759.1 hypothetical protein -
LE167_RS07890 (LE167_07915) 1655704..1655874 - 171 WP_002458758.1 SAS053 family protein Toxin
LE167_RS07895 (LE167_07920) 1655914..1656513 - 600 WP_002458757.1 glucosamine-6-phosphate isomerase Antitoxin
LE167_RS07900 (LE167_07925) 1656679..1657149 - 471 WP_002458756.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LE167_RS07905 (LE167_07930) 1657151..1658278 - 1128 WP_002477976.1 tRNA epoxyqueuosine(34) reductase QueG -
LE167_RS07910 (LE167_07935) 1658751..1659476 - 726 WP_002477975.1 amino acid ABC transporter ATP-binding protein -
LE167_RS07915 (LE167_07940) 1659469..1660926 - 1458 WP_002477974.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6565.10 Da        Isoelectric Point: 4.6723

>T218645 WP_002458758.1 NZ_CP084443:c1655874-1655704 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Download         Length: 171 bp

>T218645 NZ_CP116071:177628-177735 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22619.51 Da        Isoelectric Point: 4.9539

>AT218645 WP_002458757.1 NZ_CP084443:c1656513-1655914 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Download         Length: 600 bp

>AT218645 NZ_CP116071:c177571-177514 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V5R2

References