Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2629085..2629884 Replicon chromosome
Accession NZ_CP084440
Organism Staphylococcus lugdunensis strain RMLUG4

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LE164_RS12600 Protein ID WP_267262642.1
Coordinates 2629420..2629884 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LE164_RS12595 Protein ID WP_070817183.1
Coordinates 2629085..2629408 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LE164_RS12535 (LE164_12545) 2624113..2624901 - 789 WP_267262637.1 ATP-binding protein -
LE164_RS12540 (LE164_12550) 2624894..2625118 - 225 WP_267262638.1 DUF2483 family protein -
LE164_RS12545 (LE164_12555) 2625090..2625365 - 276 WP_267262639.1 hypothetical protein -
LE164_RS12550 (LE164_12560) 2625429..2625608 - 180 WP_267262640.1 hypothetical protein -
LE164_RS12555 (LE164_12565) 2625836..2626219 + 384 WP_002478859.1 hypothetical protein -
LE164_RS12560 (LE164_12570) 2626167..2626478 - 312 WP_070866275.1 hypothetical protein -
LE164_RS12565 (LE164_12575) 2626516..2626743 - 228 WP_237622948.1 hypothetical protein -
LE164_RS12570 (LE164_12580) 2626755..2627342 - 588 WP_107638322.1 hypothetical protein -
LE164_RS12575 (LE164_12585) 2627345..2628232 - 888 WP_267262641.1 DUF3102 domain-containing protein -
LE164_RS12580 (LE164_12590) 2628288..2628497 + 210 WP_000033736.1 hypothetical protein -
LE164_RS12585 (LE164_12595) 2628486..2628656 - 171 WP_176746548.1 hypothetical protein -
LE164_RS12590 (LE164_12600) 2628672..2628920 - 249 WP_070817182.1 helix-turn-helix transcriptional regulator -
LE164_RS12595 (LE164_12605) 2629085..2629408 + 324 WP_070817183.1 helix-turn-helix transcriptional regulator Antitoxin
LE164_RS12600 (LE164_12610) 2629420..2629884 + 465 WP_267262642.1 ImmA/IrrE family metallo-endopeptidase Toxin
LE164_RS12605 (LE164_12615) 2629936..2630442 + 507 WP_070481548.1 hypothetical protein -
LE164_RS12610 (LE164_12620) 2630508..2631890 + 1383 WP_267262643.1 recombinase family protein -
LE164_RS12615 (LE164_12625) 2631912..2632790 - 879 Protein_2438 PTS transporter subunit EIIC -
LE164_RS12620 (LE164_12630) 2632799..2633110 - 312 WP_002460006.1 PTS lactose transporter subunit IIA -
LE164_RS12625 (LE164_12635) 2633130..2634104 - 975 WP_002460008.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2592605..2637936 45331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(19-118)

Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18329.86 Da        Isoelectric Point: 5.6836

>T218644 WP_267262642.1 NZ_CP084440:2629420-2629884 [Staphylococcus lugdunensis]
MGLYEEMLIKHDYIEIKETDVMPDNLSGVWLDDLILINSNLPETRKTEVLYEELAHHKLTYGNILDQSKWINRKFENYAR
RHGYEVALPLRIIVEAHHYGVSNLYELAEYVQLSEEHVLEILEHYKQKHGIGIHYGEYSITFEPLRVFKLHHID

Download         Length: 465 bp

>T218644 NZ_CP116070:c19993-19607 [Escherichia coli]
ATGAAATTCGTTAGTTCACAGGAAGTGATTGAGTTTCATGACCGCTTGATTTCGCGTGATGGTGGCGTGGCGGGTATGCC
AGAACCCGGTCGCGCTGACGCGATCATTCATCGTGTTTTGAACATGTATCATTATGAAGGTGTGACAGATATTATGGATC
TGGCTGCCGTGTATTTAGTTGCTATTGCTCGTGGTCACATTTTCAACGATGCAAATAAGCGAACAGCCTTGTTTGTTGCA
CAGGTTTTTTTAAAACGGAATGGTGTACATATTATTAGTTCACGTATTTCGTTTGATGAAATGCAAATTATCGCTTTGAA
TGCTGCAACAGGAGAATATAACTGGAAGATGGTTTCTGACCATCTTAAAGCCATTATTCTAAATTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12266.97 Da        Isoelectric Point: 9.7735

>AT218644 WP_070817183.1 NZ_CP084440:2629085-2629408 [Staphylococcus lugdunensis]
MRTSAEIGKLIKQLRKKNNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALNVTPESLLLKNKQPETEVQHRA
AHLEGELTDDEWQRVLDYADYIKSKRK

Download         Length: 324 bp

>AT218644 NZ_CP116070:c20214-19990 [Escherichia coli]
ATGTTTACATGTAACTATAGCCATGCTCGCGATAACCTGGCCTCGTTGCTCGAGCTGGCGGTTGATGAAAATCAGCCAGT
TGAGATTCAGCGCCGTAAAGGTGGCGCAGCTGTACTGGTTGATAAAGACGCTTTTGAACGATACCGTAAAGCGGCTCTTG
ATGCTGAGTTTGCTGAGATCATGCAAAGTCATGGGACGGCCTATACGGAGCTTTCTAAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References