Detailed information of TA system TA218641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2345249..2346058
• Replicon: chromosome
• Accession: NZ_CP084440
• Organism: Staphylococcus lugdunensis strain RMLUG4

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: LE164_RS10945
• Protein ID: WP_002458758.1
• Coordinates: 2345249..2345419 (-)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: LE164_RS10950
• Protein ID: WP_002458757.1
• Coordinates: 2345459..2346058 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LE164_RS10920 (LE164_10935)	2340341..2340964	-	624	WP_002477980.1	response regulator transcription factor	-
LE164_RS10925 (LE164_10940)	2340986..2342098	-	1113	WP_002477979.1	GAF domain-containing sensor histidine kinase	-
LE164_RS10930 (LE164_10945)	2342266..2343102	+	837	WP_002477978.1	RluA family pseudouridine synthase	-
LE164_RS10935 (LE164_10950)	2343167..2344552	-	1386	WP_002477977.1	class II fumarate hydratase	-
LE164_RS10940 (LE164_10955)	2344680..2345075	-	396	WP_002458759.1	hypothetical protein	-
LE164_RS10945 (LE164_10960)	2345249..2345419	-	171	WP_002458758.1	SAS053 family protein	Toxin
LE164_RS10950 (LE164_10965)	2345459..2346058	-	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
LE164_RS10955 (LE164_10970)	2346224..2346694	-	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LE164_RS10960 (LE164_10975)	2346696..2347823	-	1128	WP_002477976.1	tRNA epoxyqueuosine(34) reductase QueG	-
LE164_RS10965 (LE164_10980)	2348296..2349021	-	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
LE164_RS10970 (LE164_10985)	2349014..2350471	-	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T218641 WP_002458758.1 NZ_CP084440:c2345419-2345249 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T218641 NZ_CP116068:86322-86603 [Escherichia coli]
ATGACTTATGAACTGGAATTTGAGCGCAGGGCCCTGAAAGAATGGCATAAGCTCGGTCATACAGTCCGTGAGCAGTTCAA
AAAGAAACTGTCAGAACGCCTGAAAAATCCAAGGGTCCCTGCTGCCAGGCTACATGGTCATACTGACCGTTATAAAATCA
AGCTTCGTGCATCTGGTTACAGGCTCGTCTATCAGGTGATTGATGAGAAAATTGTTTTGCTCGTTATTGCTGTAGGAAAA
AGGGAAAGCAGTGAGGTCTACCAGATGGCTGATATTCGCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT218641 WP_002458757.1 NZ_CP084440:c2346058-2345459 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT218641 NZ_CP116068:86081-86332 [Escherichia coli]
ATGAGTTACCAGATTTTGACCACGACAGCAGCAAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACGGTAGCCGAAGG
TGAAGGAGGGGCCGTTGCAATCCTGAACCGAAATGAGCCTGCGTTCTACTGTGTCCCTCCGGAACTTTATGCCTACTACC
GGGAGCTCGCCGAAGATGCTGAGCTAAACGCAATTGCTGATGAAAGAATGAAGAATCCGGACATTGTGAAGGTTAGTCTG
GATGACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2