Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 503293..503828 | Replicon | chromosome |
| Accession | NZ_CP084437 | ||
| Organism | Staphylococcus lugdunensis strain RMLUG3 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | C5QLS6 |
| Locus tag | LE166_RS02480 | Protein ID | WP_002445368.1 |
| Coordinates | 503505..503828 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | C5QLS5 |
| Locus tag | LE166_RS02475 | Protein ID | WP_001058489.1 |
| Coordinates | 503293..503502 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LE166_RS02440 (LE166_02440) | 498549..498833 | + | 285 | WP_002461410.1 | co-chaperone GroES | - |
| LE166_RS02445 (LE166_02445) | 498893..500515 | + | 1623 | WP_267262507.1 | chaperonin GroEL | - |
| LE166_RS02450 (LE166_02450) | 500584..501756 | - | 1173 | WP_002492309.1 | tyrosine-type recombinase/integrase | - |
| LE166_RS02455 (LE166_02455) | 501770..502444 | - | 675 | WP_002445345.1 | helix-turn-helix transcriptional regulator | - |
| LE166_RS02460 (LE166_02460) | 502617..502835 | + | 219 | WP_000153640.1 | helix-turn-helix transcriptional regulator | - |
| LE166_RS02465 (LE166_02465) | 502840..503157 | + | 318 | WP_002445364.1 | helix-turn-helix domain-containing protein | - |
| LE166_RS02470 (LE166_02470) | 503154..503300 | + | 147 | WP_002445365.1 | hypothetical protein | - |
| LE166_RS02475 (LE166_02475) | 503293..503502 | + | 210 | WP_001058489.1 | hypothetical protein | Antitoxin |
| LE166_RS02480 (LE166_02480) | 503505..503828 | + | 324 | WP_002445368.1 | DUF1474 family protein | Toxin |
| LE166_RS02485 (LE166_02485) | 503892..504761 | + | 870 | WP_002445370.1 | primase alpha helix C-terminal domain-containing protein | - |
| LE166_RS02490 (LE166_02490) | 504775..506484 | + | 1710 | WP_002445371.1 | DUF927 domain-containing protein | - |
| LE166_RS02495 (LE166_02495) | 506832..507197 | + | 366 | WP_002445372.1 | hypothetical protein | - |
| LE166_RS02500 (LE166_02500) | 507211..507852 | + | 642 | WP_002492310.1 | pathogenicity island protein | - |
| LE166_RS02505 (LE166_02505) | 508140..508484 | + | 345 | WP_002445374.1 | hypothetical protein | - |
| LE166_RS02510 (LE166_02510) | 508498..508731 | + | 234 | WP_002492317.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL | 494884..519870 | 24986 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 13107.51 Da Isoelectric Point: 4.8571
>T218639 WP_002445368.1 NZ_CP084437:503505-503828 [Staphylococcus lugdunensis]
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE
MNWEIKNLFSDLKLLKDSFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIQ
KFHELEKASSENFGEESDDAQKLKITE
Download Length: 324 bp
>T218639 NZ_CP116067:c5253763-5253377 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8225.24 Da Isoelectric Point: 4.2820
>AT218639 WP_001058489.1 NZ_CP084437:503293-503502 [Staphylococcus lugdunensis]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT218639 NZ_CP116067:c5253387-5253058 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853V3H1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A853V601 |