Detailed information of TA system TA218634

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 572502..573311
• Replicon: chromosome
• Accession: NZ_CP084434
• Organism: Staphylococcus lugdunensis strain RMLUG2

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: LE165_RS02710
• Protein ID: WP_002458758.1
• Coordinates: 572502..572672 (-)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: LE165_RS02715
• Protein ID: WP_002458757.1
• Coordinates: 572712..573311 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LE165_RS02685 (LE165_02700)	567594..568217	-	624	WP_002477980.1	response regulator transcription factor	-
LE165_RS02690 (LE165_02705)	568239..569351	-	1113	WP_084951535.1	GAF domain-containing sensor histidine kinase	-
LE165_RS02695 (LE165_02710)	569519..570355	+	837	WP_084951533.1	RluA family pseudouridine synthase	-
LE165_RS02700 (LE165_02715)	570420..571805	-	1386	WP_070648688.1	class II fumarate hydratase	-
LE165_RS02705 (LE165_02720)	571933..572328	-	396	WP_037545575.1	hypothetical protein	-
LE165_RS02710 (LE165_02725)	572502..572672	-	171	WP_002458758.1	SAS053 family protein	Toxin
LE165_RS02715 (LE165_02730)	572712..573311	-	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
LE165_RS02720 (LE165_02735)	573477..573947	-	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LE165_RS02725 (LE165_02740)	573949..575076	-	1128	WP_084951531.1	tRNA epoxyqueuosine(34) reductase QueG	-
LE165_RS02730 (LE165_02745)	575548..576273	-	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
LE165_RS02735 (LE165_02750)	576266..577723	-	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T218634 WP_002458758.1 NZ_CP084434:c572672-572502 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T218634 NZ_CP116067:3893225-3893398 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT218634 WP_002458757.1 NZ_CP084434:c573311-572712 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT218634 NZ_CP116067:3892901-3893197 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2