Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1122589..1123181 Replicon chromosome
Accession NZ_CP084433
Organism Edwardsiella piscicida strain S07-534

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCF40_RS05075 Protein ID WP_012847872.1
Coordinates 1122589..1122792 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCF40_RS05080 Protein ID WP_015461125.1
Coordinates 1122813..1123181 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF40_RS05045 (DCF40_05045) 1118308..1118769 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCF40_RS05050 (DCF40_05050) 1119074..1119412 + 339 WP_069578328.1 P-II family nitrogen regulator -
DCF40_RS05055 (DCF40_05055) 1119434..1120714 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCF40_RS05060 (DCF40_05060) 1120749..1121615 - 867 WP_226088336.1 acyl-CoA thioesterase II -
DCF40_RS05065 (DCF40_05065) 1121724..1122053 - 330 WP_225857588.1 MGMT family protein -
DCF40_RS05075 (DCF40_05075) 1122589..1122792 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCF40_RS05080 (DCF40_05080) 1122813..1123181 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCF40_RS05085 (DCF40_05085) 1123549..1126701 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCF40_RS05090 (DCF40_05090) 1126745..1127929 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218613 WP_012847872.1 NZ_CP084433:c1122792-1122589 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218613 NZ_CP116046:3992784-3993182 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218613 WP_015461125.1 NZ_CP084433:c1123181-1122813 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218613 NZ_CP116046:3992488-3992781 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGTTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References