Detailed information of TA system TA218602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1666995..1667517
• Replicon: chromosome
• Accession: NZ_CP084432
• Organism: Edwardsiella tarda strain AL98-87

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D4F5Y1
• Locus tag: DCF75_RS07690
• Protein ID: WP_005286355.1
• Coordinates: 1666995..1667276 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4F5Y0
• Locus tag: DCF75_RS07695
• Protein ID: WP_005286352.1
• Coordinates: 1667266..1667517 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCF75_RS07675 (DCF75_07675)	1662643..1663158	+	516	WP_226086043.1	hypothetical protein	-
DCF75_RS07680 (DCF75_07680)	1663151..1664812	+	1662	WP_005286362.1	hypothetical protein	-
DCF75_RS07685 (DCF75_07685)	1664809..1666923	+	2115	WP_116604770.1	portal protein	-
DCF75_RS07690 (DCF75_07690)	1666995..1667276	-	282	WP_005286355.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DCF75_RS07695 (DCF75_07695)	1667266..1667517	-	252	WP_005286352.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DCF75_RS07700 (DCF75_07700)	1667796..1668800	+	1005	WP_116604772.1	hypothetical protein	-
DCF75_RS07705 (DCF75_07705)	1668818..1670062	+	1245	WP_005286350.1	N4-gp56 family major capsid protein	-
DCF75_RS07710 (DCF75_07710)	1670118..1670522	+	405	WP_116604774.1	hypothetical protein	-
DCF75_RS07715 (DCF75_07715)	1670564..1671028	+	465	WP_005286344.1	hypothetical protein	-
DCF75_RS07720 (DCF75_07720)	1671015..1671596	+	582	WP_226086044.1	hypothetical protein	-
DCF75_RS07725 (DCF75_07725)	1671596..1672258	+	663	WP_116604778.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1624135..1678697	54562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10852.69 Da
• Isoelectric Point: 10.7535

>T218602 WP_005286355.1 NZ_CP084432:c1667276-1666995 [Edwardsiella tarda]
MTYKLSFEKRALKEWKRLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRASGYRLVYEVNDNEIILLVIAIGK
RADNEVYQTADSR

Nucleotide

• Length: 282 bp

>T218602 NZ_CP116046:1116744-1117118 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9128.22 Da
• Isoelectric Point: 3.7550

>AT218602 WP_005286352.1 NZ_CP084432:c1667517-1667266 [Edwardsiella tarda]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVSI
DDL

Nucleotide

• Length: 252 bp

>AT218602 NZ_CP116046:1116287-1116655 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: D4F5Y1

Antitoxin

• AlphaFold DB: D4F5Y0