Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 552006..552675 Replicon chromosome
Accession NZ_CP084432
Organism Edwardsiella tarda strain AL98-87

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A7U6Y8
Locus tag DCF75_RS02495 Protein ID WP_005296363.1
Coordinates 552253..552675 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2A7U0A3
Locus tag DCF75_RS02490 Protein ID WP_005296359.1
Coordinates 552006..552272 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF75_RS02470 (DCF75_02470) 547250..547900 - 651 WP_005282104.1 hemolysin III family protein -
DCF75_RS02475 (DCF75_02475) 548476..549351 + 876 WP_005282096.1 nucleoside-specific channel-forming protein Tsx -
DCF75_RS02480 (DCF75_02480) 549562..550386 + 825 WP_005282094.1 shikimate 5-dehydrogenase -
DCF75_RS02485 (DCF75_02485) 550439..551434 - 996 WP_005296356.1 tRNA-modifying protein YgfZ -
DCF75_RS02490 (DCF75_02490) 552006..552272 + 267 WP_005296359.1 FAD assembly factor SdhE Antitoxin
DCF75_RS02495 (DCF75_02495) 552253..552675 + 423 WP_005296363.1 protein YgfX Toxin
DCF75_RS02500 (DCF75_02500) 552759..553277 - 519 WP_005282086.1 flavodoxin FldB -
DCF75_RS02505 (DCF75_02505) 553415..554314 + 900 WP_005282082.1 site-specific tyrosine recombinase XerD -
DCF75_RS02510 (DCF75_02510) 554342..555058 + 717 WP_005282080.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DCF75_RS02515 (DCF75_02515) 555063..556796 + 1734 WP_005296366.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-134)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16231.84 Da        Isoelectric Point: 9.3042

>T218600 WP_005296363.1 NZ_CP084432:552253-552675 [Edwardsiella tarda]
VAPWCCNVHVSWRTQVIALLGYGALVLTILLAPWPESYGVSAFWLLLLVVVIFECIRSQRRIARNRGELQYSATGEWRWQ
QREWRLARRPWISDMGVLLLLQSSAGPARRRRLWLAADSMSQEEWSELRALLLNAPETND

Download         Length: 423 bp

>T218600 NZ_CP116046:c633419-632136 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGTGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAATGGGGTTTGGTCATTG
TTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10325.96 Da        Isoelectric Point: 5.6819

>AT218600 WP_005296359.1 NZ_CP084432:552006-552272 [Edwardsiella tarda]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDAMSDADKQTFVRLLNCDDPELFKWLMNQGVPEDADLARMITLIQTRN
KARGPMVL

Download         Length: 267 bp

>AT218600 NZ_CP116046:c633685-633419 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7U6Y8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7U0A3

References