Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3216807..3217470 Replicon chromosome
Accession NZ_CP084430
Organism Edwardsiella piscicida strain S07-348

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag DCF39_RS14780 Protein ID WP_041692803.1
Coordinates 3216807..3217223 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag DCF39_RS14785 Protein ID WP_012849755.1
Coordinates 3217204..3217470 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF39_RS14760 (DCF39_14775) 3212738..3214471 - 1734 WP_015462273.1 single-stranded-DNA-specific exonuclease RecJ -
DCF39_RS14765 (DCF39_14780) 3214476..3215192 - 717 WP_015462274.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DCF39_RS14770 (DCF39_14785) 3215220..3216119 - 900 WP_015462275.1 site-specific tyrosine recombinase XerD -
DCF39_RS14775 (DCF39_14790) 3216270..3216782 + 513 WP_012849753.1 flavodoxin FldB -
DCF39_RS14780 (DCF39_14795) 3216807..3217223 - 417 WP_041692803.1 protein YgfX Toxin
DCF39_RS14785 (DCF39_14800) 3217204..3217470 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
DCF39_RS14790 (DCF39_14805) 3217818..3218816 + 999 WP_015462277.1 tRNA-modifying protein YgfZ -
DCF39_RS14795 (DCF39_14810) 3218859..3219683 - 825 WP_015462278.1 shikimate 5-dehydrogenase -
DCF39_RS14800 (DCF39_14815) 3219842..3220714 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
DCF39_RS14805 (DCF39_14820) 3221323..3221973 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16243.06 Da        Isoelectric Point: 11.6049

>T218598 WP_041692803.1 NZ_CP084430:c3217223-3216807 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGTLVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T218598 NZ_CP116046:c330811-330704 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT218598 WP_012849755.1 NZ_CP084430:c3217470-3217204 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT218598 NZ_CP116046:330858-330924 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References