Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1082693..1083285 Replicon chromosome
Accession NZ_CP084430
Organism Edwardsiella piscicida strain S07-348

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCF39_RS04825 Protein ID WP_012847872.1
Coordinates 1082693..1082896 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCF39_RS04830 Protein ID WP_015461125.1
Coordinates 1082917..1083285 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF39_RS04795 (DCF39_04800) 1078418..1078879 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCF39_RS04800 (DCF39_04805) 1079184..1079522 + 339 WP_012847867.1 P-II family nitrogen regulator -
DCF39_RS04805 (DCF39_04810) 1079544..1080824 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCF39_RS04810 (DCF39_04815) 1080859..1081725 - 867 WP_012847869.1 acyl-CoA thioesterase II -
DCF39_RS04815 (DCF39_04820) 1081835..1082164 - 330 WP_225857588.1 MGMT family protein -
DCF39_RS04825 (DCF39_04830) 1082693..1082896 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCF39_RS04830 (DCF39_04835) 1082917..1083285 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCF39_RS04835 (DCF39_04840) 1083653..1086805 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCF39_RS04840 (DCF39_04845) 1086849..1088033 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218580 WP_012847872.1 NZ_CP084430:c1082896-1082693 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218580 NZ_CP084430:c1082896-1082693 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218580 WP_015461125.1 NZ_CP084430:c1083285-1082917 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218580 NZ_CP084430:c1083285-1082917 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGTTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References