Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3138761..3139424 Replicon chromosome
Accession NZ_CP084429
Organism Edwardsiella piscicida strain S07-346

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag DCF38_RS14435 Protein ID WP_034167931.1
Coordinates 3138761..3139177 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag DCF38_RS14440 Protein ID WP_012849755.1
Coordinates 3139158..3139424 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF38_RS14415 (DCF38_14415) 3134692..3136425 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
DCF38_RS14420 (DCF38_14420) 3136430..3137146 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DCF38_RS14425 (DCF38_14425) 3137174..3138073 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
DCF38_RS14430 (DCF38_14430) 3138224..3138736 + 513 WP_012849753.1 flavodoxin FldB -
DCF38_RS14435 (DCF38_14435) 3138761..3139177 - 417 WP_034167931.1 protein YgfX Toxin
DCF38_RS14440 (DCF38_14440) 3139158..3139424 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
DCF38_RS14445 (DCF38_14445) 3139778..3140776 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
DCF38_RS14450 (DCF38_14450) 3140819..3141643 - 825 WP_109745894.1 shikimate 5-dehydrogenase -
DCF38_RS14455 (DCF38_14455) 3141802..3142674 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
DCF38_RS14460 (DCF38_14460) 3143283..3143933 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T218578 WP_034167931.1 NZ_CP084429:c3139177-3138761 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T218578 NZ_CP116044:c2161737-2161630 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGACAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT218578 WP_012849755.1 NZ_CP084429:c3139424-3139158 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT218578 NZ_CP116044:2161785-2161851 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References