Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1130305..1130897 Replicon chromosome
Accession NZ_CP084429
Organism Edwardsiella piscicida strain S07-346

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCF38_RS05110 Protein ID WP_012847872.1
Coordinates 1130305..1130508 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCF38_RS05115 Protein ID WP_015461125.1
Coordinates 1130529..1130897 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF38_RS05080 (DCF38_05080) 1125981..1126442 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCF38_RS05085 (DCF38_05085) 1126747..1127085 + 339 WP_012847867.1 P-II family nitrogen regulator -
DCF38_RS05090 (DCF38_05090) 1127107..1128387 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCF38_RS05095 (DCF38_05095) 1128422..1129288 - 867 WP_012847869.1 acyl-CoA thioesterase II -
DCF38_RS05100 (DCF38_05100) 1129397..1129726 - 330 WP_225857588.1 MGMT family protein -
DCF38_RS05110 (DCF38_05110) 1130305..1130508 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCF38_RS05115 (DCF38_05115) 1130529..1130897 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCF38_RS05120 (DCF38_05120) 1131266..1134418 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCF38_RS05125 (DCF38_05125) 1134462..1135646 - 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218576 WP_012847872.1 NZ_CP084429:c1130508-1130305 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218576 NZ_CP116044:c1329939-1329397 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218576 WP_015461125.1 NZ_CP084429:c1130897-1130529 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218576 NZ_CP116044:c1330234-1329923 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References