Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3143417..3144080 Replicon chromosome
Accession NZ_CP084428
Organism Edwardsiella piscicida strain S07-275

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag DCF36_RS14495 Protein ID WP_034167931.1
Coordinates 3143417..3143833 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag DCF36_RS14500 Protein ID WP_012849755.1
Coordinates 3143814..3144080 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF36_RS14475 (DCF36_14475) 3139348..3141081 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
DCF36_RS14480 (DCF36_14480) 3141086..3141802 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DCF36_RS14485 (DCF36_14485) 3141830..3142729 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
DCF36_RS14490 (DCF36_14490) 3142880..3143392 + 513 WP_012849753.1 flavodoxin FldB -
DCF36_RS14495 (DCF36_14495) 3143417..3143833 - 417 WP_034167931.1 protein YgfX Toxin
DCF36_RS14500 (DCF36_14500) 3143814..3144080 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
DCF36_RS14505 (DCF36_14505) 3144434..3145432 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
DCF36_RS14510 (DCF36_14510) 3145475..3146299 - 825 WP_109745894.1 shikimate 5-dehydrogenase -
DCF36_RS14515 (DCF36_14515) 3146458..3147330 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
DCF36_RS14520 (DCF36_14520) 3147939..3148589 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T218574 WP_034167931.1 NZ_CP084428:c3143833-3143417 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

>T218574 NZ_CP116044:519346-519519 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT218574 WP_012849755.1 NZ_CP084428:c3144080-3143814 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT218574 NZ_CP116044:519022-519318 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References