Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2938590..2939322 Replicon chromosome
Accession NZ_CP084428
Organism Edwardsiella piscicida strain S07-275

Toxin (Protein)


Gene name ypjF Uniprot ID A0A411H496
Locus tag DCF36_RS13585 Protein ID WP_015683453.1
Coordinates 2938993..2939322 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A411H489
Locus tag DCF36_RS13580 Protein ID WP_015683452.1
Coordinates 2938590..2938955 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF36_RS13535 (DCF36_13535) 2933832..2934545 + 714 WP_041692656.1 WYL domain-containing protein -
DCF36_RS13540 (DCF36_13540) 2934542..2935162 + 621 WP_041692657.1 hypothetical protein -
DCF36_RS13545 (DCF36_13545) 2935197..2935649 + 453 WP_015683446.1 hypothetical protein -
DCF36_RS13550 (DCF36_13550) 2935646..2936095 + 450 WP_015683447.1 IrmA family protein -
DCF36_RS13555 (DCF36_13555) 2936167..2936397 + 231 WP_015683448.1 DUF905 domain-containing protein -
DCF36_RS13560 (DCF36_13560) 2936496..2937317 + 822 WP_041692658.1 DUF932 domain-containing protein -
DCF36_RS13565 (DCF36_13565) 2937348..2937791 + 444 WP_047414857.1 antirestriction protein -
DCF36_RS13570 (DCF36_13570) 2937804..2938346 + 543 WP_041692659.1 DNA repair protein RadC -
DCF36_RS13575 (DCF36_13575) 2938343..2938564 + 222 WP_015683451.1 DUF987 domain-containing protein -
DCF36_RS13580 (DCF36_13580) 2938590..2938955 + 366 WP_015683452.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DCF36_RS13585 (DCF36_13585) 2938993..2939322 + 330 WP_015683453.1 TA system toxin CbtA family protein Toxin
DCF36_RS13590 (DCF36_13590) 2939702..2939998 + 297 WP_012849576.1 YciI family protein -
DCF36_RS13595 (DCF36_13595) 2940115..2940501 - 387 WP_012849577.1 RidA family protein -
DCF36_RS13600 (DCF36_13600) 2940538..2940864 - 327 WP_012849578.1 AzlD domain-containing protein -
DCF36_RS13605 (DCF36_13605) 2940857..2941594 - 738 WP_172454870.1 AzlC family ABC transporter permease -
DCF36_RS13610 (DCF36_13610) 2941658..2942941 - 1284 WP_012849580.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2913119..2939322 26203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12617.29 Da        Isoelectric Point: 9.5061

>T218573 WP_015683453.1 NZ_CP084428:2938993-2939322 [Edwardsiella piscicida]
MQTLSSHPTRSTQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK

Download         Length: 330 bp

>T218573 NZ_CP116044:390092-390640 [Escherichia coli]
ATGTCTCGCAATTCAGATATCTATAAACTTATCGGAGCGGCTGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTATACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACAGGTGCATTGCATGAGTTTATGCAGCAGCACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGCGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAACTTCGGACAAAAATGGCATCATTCACGGTTTGTTTTATGTCGTGGTGGTGCTTATTTGTAGCCGTAATGTTTG
TATCGTTTCTTATTGCTCATGAAGGAAAGCCTCCAGTTGAAGCAATCGTTGCATTACTAGGTACAAGTACAATTAGCATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13477.21 Da        Isoelectric Point: 5.8743

>AT218573 WP_015683452.1 NZ_CP084428:2938590-2938955 [Edwardsiella piscicida]
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH

Download         Length: 366 bp

>AT218573 NZ_CP116044:389596-390069 [Escherichia coli]
ATGTACAGCCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAACGAATGTGTCTCTGCGT
GGAAGTACGGTCCGGTTATTCCCGGAATGTACGATGCTTTCAAAGATTATGGGAATAAGCCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATTGTTACTATGGATCCGCAAGCAGAGAGCATTATAGGGGCTGTTTATAAATTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAACTTATAATGGTATTGGCTCGTCAA
TCATCCCAGATGATGCGATCAAGACTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H496

Antitoxin

Source ID Structure
AlphaFold DB A0A411H489

References