Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1097624..1098216 Replicon chromosome
Accession NZ_CP084428
Organism Edwardsiella piscicida strain S07-275

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCF36_RS04915 Protein ID WP_012847872.1
Coordinates 1097624..1097827 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCF36_RS04920 Protein ID WP_015461125.1
Coordinates 1097848..1098216 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF36_RS04885 (DCF36_04885) 1093314..1093775 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCF36_RS04890 (DCF36_04890) 1094080..1094418 + 339 WP_012847867.1 P-II family nitrogen regulator -
DCF36_RS04895 (DCF36_04895) 1094440..1095720 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCF36_RS04900 (DCF36_04900) 1095755..1096621 - 867 WP_012847869.1 acyl-CoA thioesterase II -
DCF36_RS04905 (DCF36_04905) 1096730..1097059 - 330 WP_225857588.1 MGMT family protein -
DCF36_RS04915 (DCF36_04915) 1097624..1097827 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCF36_RS04920 (DCF36_04920) 1097848..1098216 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCF36_RS04925 (DCF36_04925) 1098585..1101737 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCF36_RS04930 (DCF36_04930) 1101781..1102965 - 1185 WP_034168424.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218572 WP_012847872.1 NZ_CP084428:c1097827-1097624 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218572 NZ_CP116044:197312-197623 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218572 WP_015461125.1 NZ_CP084428:c1098216-1097848 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218572 NZ_CP116044:197624-197914 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References