Detailed information of TA system TA218570

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3119764..3120427
• Replicon: chromosome
• Accession: NZ_CP084427
• Organism: Edwardsiella piscicida strain S07-262

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DCF34_RS14200
• Protein ID: WP_041692803.1
• Coordinates: 3119764..3120180 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: DCF34_RS14205
• Protein ID: WP_012849755.1
• Coordinates: 3120161..3120427 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCF34_RS14180 (DCF34_14180)	3115695..3117428	-	1734	WP_015462273.1	single-stranded-DNA-specific exonuclease RecJ	-
DCF34_RS14185 (DCF34_14185)	3117433..3118149	-	717	WP_015462274.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DCF34_RS14190 (DCF34_14190)	3118177..3119076	-	900	WP_015462275.1	site-specific tyrosine recombinase XerD	-
DCF34_RS14195 (DCF34_14195)	3119227..3119739	+	513	WP_012849753.1	flavodoxin FldB	-
DCF34_RS14200 (DCF34_14200)	3119764..3120180	-	417	WP_041692803.1	protein YgfX	Toxin
DCF34_RS14205 (DCF34_14205)	3120161..3120427	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
DCF34_RS14210 (DCF34_14210)	3120775..3121773	+	999	WP_015462277.1	tRNA-modifying protein YgfZ	-
DCF34_RS14215 (DCF34_14215)	3121816..3122640	-	825	WP_015462278.1	shikimate 5-dehydrogenase	-
DCF34_RS14220 (DCF34_14220)	3122799..3123671	-	873	WP_012849758.1	nucleoside-specific channel-forming protein Tsx	-
DCF34_RS14225 (DCF34_14225)	3124280..3124930	+	651	WP_015462279.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16243.06 Da
• Isoelectric Point: 11.6049

>T218570 WP_041692803.1 NZ_CP084427:c3120180-3119764 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGTLVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Nucleotide

• Length: 417 bp

>T218570 NZ_CP116042:4803340-4803651 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT218570 WP_012849755.1 NZ_CP084427:c3120427-3120161 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT218570 NZ_CP116042:4803648-4804094 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8