Detailed information of TA system TA218560

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3182583..3183246
• Replicon: chromosome
• Accession: NZ_CP084424
• Organism: Edwardsiella piscicida strain MA97-004

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DCE91_RS14605
• Protein ID: WP_041692803.1
• Coordinates: 3182583..3182999 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D0ZDY6
• Locus tag: DCE91_RS14610
• Protein ID: WP_012849755.1
• Coordinates: 3182980..3183246 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCE91_RS14585 (DCE91_14585)	3178514..3180247	-	1734	WP_015462273.1	single-stranded-DNA-specific exonuclease RecJ	-
DCE91_RS14590 (DCE91_14590)	3180252..3180968	-	717	WP_015462274.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DCE91_RS14595 (DCE91_14595)	3180996..3181895	-	900	WP_015462275.1	site-specific tyrosine recombinase XerD	-
DCE91_RS14600 (DCE91_14600)	3182046..3182558	+	513	WP_012849753.1	flavodoxin FldB	-
DCE91_RS14605 (DCE91_14605)	3182583..3182999	-	417	WP_041692803.1	protein YgfX	Toxin
DCE91_RS14610 (DCE91_14610)	3182980..3183246	-	267	WP_012849755.1	FAD assembly factor SdhE	Antitoxin
DCE91_RS14615 (DCE91_14615)	3183594..3184592	+	999	WP_015462277.1	tRNA-modifying protein YgfZ	-
DCE91_RS14620 (DCE91_14620)	3184635..3185459	-	825	WP_015462278.1	shikimate 5-dehydrogenase	-
DCE91_RS14625 (DCE91_14625)	3185618..3186490	-	873	WP_012849758.1	nucleoside-specific channel-forming protein Tsx	-
DCE91_RS14630 (DCE91_14630)	3187099..3187749	+	651	WP_015462279.1	hemolysin III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16243.06 Da
• Isoelectric Point: 11.6049

>T218560 WP_041692803.1 NZ_CP084424:c3182999-3182583 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGTLVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Nucleotide

• Length: 417 bp

>T218560 NZ_CP116042:881189-881587 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10318.90 Da
• Isoelectric Point: 5.6951

>AT218560 WP_012849755.1 NZ_CP084424:c3183246-3182980 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Nucleotide

• Length: 267 bp

>AT218560 NZ_CP116042:880962-881189 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A034T2Q8