Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 784393..785026 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag BCG_RS03610 Protein ID WP_003403365.1
Coordinates 784393..784776 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag BCG_RS03615 Protein ID WP_003403368.1
Coordinates 784871..785026 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS03585 779685..780221 + 537 WP_003403341.1 50S ribosomal protein L10 -
BCG_RS03590 780258..780650 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
BCG_RS03595 780643..781338 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
BCG_RS03600 781409..782914 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
BCG_RS03605 782995..784005 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
BCG_RS03610 784393..784776 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
BCG_RS03615 784871..785026 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCG_RS03620 785102..785818 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
BCG_RS03625 786094..786402 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
BCG_RS03630 786389..786634 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
BCG_RS03635 786744..787181 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
BCG_RS03640 787178..787432 - 255 WP_003911263.1 antitoxin VapB7 -
BCG_RS03645 787546..789909 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T21856 WP_003403365.1 NC_008769:c784776-784393 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T21856 NC_008769:c784776-784393 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT21856 WP_003403368.1 NC_008769:c785026-784871 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT21856 NC_008769:c785026-784871 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References