Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1082797..1083389 Replicon chromosome
Accession NZ_CP084424
Organism Edwardsiella piscicida strain MA97-004

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag DCE91_RS04825 Protein ID WP_012847872.1
Coordinates 1082797..1083000 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A411GZW1
Locus tag DCE91_RS04830 Protein ID WP_015461125.1
Coordinates 1083021..1083389 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCE91_RS04795 (DCE91_04795) 1078410..1078871 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
DCE91_RS04800 (DCE91_04800) 1079176..1079514 + 339 WP_012847867.1 P-II family nitrogen regulator -
DCE91_RS04805 (DCE91_04805) 1079536..1080816 + 1281 WP_041692495.1 ammonium transporter AmtB -
DCE91_RS04810 (DCE91_04810) 1080851..1081717 - 867 WP_012847869.1 acyl-CoA thioesterase II -
DCE91_RS04815 (DCE91_04815) 1081827..1082156 - 330 WP_225857588.1 MGMT family protein -
DCE91_RS04825 (DCE91_04825) 1082797..1083000 - 204 WP_012847872.1 HHA domain-containing protein Toxin
DCE91_RS04830 (DCE91_04830) 1083021..1083389 - 369 WP_015461125.1 Hha toxicity modulator TomB Antitoxin
DCE91_RS04835 (DCE91_04835) 1083757..1086909 - 3153 WP_012847874.1 efflux RND transporter permease subunit -
DCE91_RS04840 (DCE91_04840) 1086953..1088137 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T218551 WP_012847872.1 NZ_CP084424:c1083000-1082797 [Edwardsiella piscicida]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T218551 NZ_CP116037:c53523-53107 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14099.80 Da        Isoelectric Point: 6.1484

>AT218551 WP_015461125.1 NZ_CP084424:c1083389-1083021 [Edwardsiella piscicida]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT218551 NZ_CP116037:c53750-53520 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB A0A411GZW1

References