Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875917..876574 Replicon chromosome
Accession NZ_CP084415
Organism Klebsiella michiganensis strain YL6-1

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag LDP80_RS04250 Protein ID WP_004854060.1
Coordinates 876164..876574 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag LDP80_RS04245 Protein ID WP_004124953.1
Coordinates 875917..876183 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDP80_RS04230 (LDP80_04235) 871151..871576 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
LDP80_RS04235 (LDP80_04240) 871697..874495 - 2799 WP_014839506.1 transcriptional regulator DagR -
LDP80_RS04240 (LDP80_04245) 874689..875672 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
LDP80_RS04245 (LDP80_04250) 875917..876183 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
LDP80_RS04250 (LDP80_04255) 876164..876574 + 411 WP_004854060.1 protein YgfX Toxin
LDP80_RS04255 (LDP80_04260) 876583..877104 - 522 WP_014226792.1 flavodoxin FldB -
LDP80_RS04260 (LDP80_04265) 877226..878122 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LDP80_RS04265 (LDP80_04270) 878145..878858 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LDP80_RS04270 (LDP80_04275) 878864..880597 + 1734 WP_014226791.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T218536 WP_004854060.1 NZ_CP084415:876164-876574 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T218536 NZ_CP116035:2483566-2483844 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT218536 WP_004124953.1 NZ_CP084415:875917-876183 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT218536 NZ_CP116035:2483844-2484128 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References