Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 5338766..5339313 Replicon chromosome
Accession NZ_CP084413
Organism Pseudomonas sp. HS-18

Toxin (Protein)


Gene name parE Uniprot ID A0A6G6J352
Locus tag LDJ84_RS24915 Protein ID WP_024762619.1
Coordinates 5339026..5339313 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0F0DTW6
Locus tag LDJ84_RS24910 Protein ID WP_024762620.1
Coordinates 5338766..5339035 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDJ84_RS24885 (LDJ84_24885) 5333944..5335071 - 1128 WP_226045563.1 GGDEF domain-containing protein -
LDJ84_RS24890 (LDJ84_24890) 5335324..5336847 + 1524 WP_024762623.1 fumarate hydratase -
LDJ84_RS24895 (LDJ84_24895) 5336979..5337281 - 303 WP_017519692.1 ribbon-helix-helix domain-containing protein -
LDJ84_RS24900 (LDJ84_24900) 5337315..5337896 - 582 WP_065084442.1 DJ-1/PfpI family protein -
LDJ84_RS24905 (LDJ84_24905) 5338000..5338578 - 579 WP_037014955.1 DUF2846 domain-containing protein -
LDJ84_RS24910 (LDJ84_24910) 5338766..5339035 + 270 WP_024762620.1 ribbon-helix-helix protein, CopG family Antitoxin
LDJ84_RS24915 (LDJ84_24915) 5339026..5339313 + 288 WP_024762619.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDJ84_RS24920 (LDJ84_24920) 5339321..5339908 - 588 WP_065084471.1 GNAT family acetyltransferase -
LDJ84_RS24925 (LDJ84_24925) 5340092..5341330 - 1239 WP_263987035.1 acyltransferase -
LDJ84_RS24930 (LDJ84_24930) 5341419..5342576 - 1158 WP_226045565.1 phospholipase D-like domain-containing protein -
LDJ84_RS24935 (LDJ84_24935) 5342573..5343148 - 576 WP_024762615.1 YceI family protein -
LDJ84_RS24940 (LDJ84_24940) 5343260..5344165 - 906 WP_226045566.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10925.54 Da        Isoelectric Point: 8.4752

>T218533 WP_024762619.1 NZ_CP084413:5339026-5339313 [Pseudomonas sp. HS-18]
MRVIYAPAALRDLDRLRRFLRETNPTAARRAGQIILQATQALGAYPQMGRLIDDLPIEFREWPIDFGDSGYIARYHIDGE
TLVILAIRHQREAGY

Download         Length: 288 bp

>T218533 NZ_CP116035:1868951-1869202 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10472.62 Da        Isoelectric Point: 4.4422

>AT218533 WP_024762620.1 NZ_CP084413:5338766-5339035 [Pseudomonas sp. HS-18]
MATSVKLDEEMLARVRELAELRQRSPHWIMREAIGQYVVREEQREKLKRDTEQAWEEFQATGQHVTAEAVESWLNSWGDE
DEQAAPKCE

Download         Length: 270 bp

>AT218533 NZ_CP116035:1869199-1869453 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6J352

Antitoxin

Source ID Structure
AlphaFold DB A0A0F0DTW6

References