Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4852202..4853335 | Replicon | chromosome |
| Accession | NZ_CP084413 | ||
| Organism | Pseudomonas sp. HS-18 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A1B8SZD5 |
| Locus tag | LDJ84_RS22570 | Protein ID | WP_065085981.1 |
| Coordinates | 4852202..4852966 (-) | Length | 255 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A1B8V7T7 |
| Locus tag | LDJ84_RS22575 | Protein ID | WP_024763405.1 |
| Coordinates | 4852967..4853335 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LDJ84_RS22555 (LDJ84_22555) | 4847611..4848501 | + | 891 | WP_065085978.1 | metal-dependent hydrolase | - |
| LDJ84_RS22560 (LDJ84_22560) | 4848590..4849936 | + | 1347 | WP_084357525.1 | FAD-binding oxidoreductase | - |
| LDJ84_RS22565 (LDJ84_22565) | 4849980..4851344 | - | 1365 | WP_167632553.1 | DNA recombination protein RmuC | - |
| LDJ84_RS22570 (LDJ84_22570) | 4852202..4852966 | - | 765 | WP_065085981.1 | RES family NAD+ phosphorylase | Toxin |
| LDJ84_RS22575 (LDJ84_22575) | 4852967..4853335 | - | 369 | WP_024763405.1 | DUF2384 domain-containing protein | Antitoxin |
| LDJ84_RS22580 (LDJ84_22580) | 4853897..4854097 | + | 201 | WP_226045429.1 | RcnB family protein | - |
| LDJ84_RS22585 (LDJ84_22585) | 4854104..4854547 | - | 444 | WP_226045430.1 | hypothetical protein | - |
| LDJ84_RS22590 (LDJ84_22590) | 4854672..4855154 | + | 483 | WP_226045431.1 | GreA/GreB family elongation factor | - |
| LDJ84_RS22595 (LDJ84_22595) | 4855288..4855635 | + | 348 | WP_017522075.1 | carboxymuconolactone decarboxylase family protein | - |
| LDJ84_RS22600 (LDJ84_22600) | 4855735..4856103 | + | 369 | WP_037015850.1 | hypothetical protein | - |
| LDJ84_RS22605 (LDJ84_22605) | 4856338..4856679 | - | 342 | WP_226045432.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LDJ84_RS22610 (LDJ84_22610) | 4856685..4856933 | - | 249 | WP_226045433.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LDJ84_RS22615 (LDJ84_22615) | 4857034..4858308 | - | 1275 | WP_226045434.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 255 a.a. Molecular weight: 28877.06 Da Isoelectric Point: 8.4428
>T218531 WP_065085981.1 NZ_CP084413:c4852966-4852202 [Pseudomonas sp. HS-18]
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPSSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA
MSFEAGARLWAKYEDSVVAPIRGRLVRLVESQGQVATLQLVDTLEEQALLEELLETSKPRMPSSAEPLHYLLKTPFRYPP
LRWGSRFGRRHEPSLFYGALKLETAMAESAFYRFVLWEGMATPPPSGRILSEHASFEARFQVQKGVRLHLPPFREHAALL
DPQDYSVTQGMGSAMRDAGVEAFEYRSARCPQGGINVALFVPSAFTEKRPRNLMPWLCETTSEYVAFKHAQVPDSPRIYR
REQYLVDGRLPHPA
Download Length: 765 bp
>T218531 NZ_CP116035:945046-945453 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13515.77 Da Isoelectric Point: 10.1440
>AT218531 WP_024763405.1 NZ_CP084413:c4853335-4852967 [Pseudomonas sp. HS-18]
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV
MSALLKENPAADTVLAKAVLTAREHLAMTQQELAAIVGVDRSAVSRWKQNGLRVDSKTGELALLLVRIYRALFALFGGNH
EDMRHFLRTENRHLGGVPLQLMERVQGLVAVVEYLDAIRGKV
Download Length: 369 bp
>AT218531 NZ_CP116035:944799-945065 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B8SZD5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1B8V7T7 |