Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 741667..742292 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag BCG_RS03390 Protein ID WP_003403218.1
Coordinates 741891..742292 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag BCG_RS03385 Protein ID WP_003403213.1
Coordinates 741667..741894 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS03355 736846..737067 - 222 WP_003898525.1 DUF4926 domain-containing protein -
BCG_RS03360 737209..737814 + 606 WP_003898526.1 hypothetical protein -
BCG_RS03365 737833..740400 - 2568 WP_003900188.1 SEC-C domain-containing protein -
BCG_RS03370 740484..741233 + 750 WP_003898528.1 hypothetical protein -
BCG_RS03375 741230..741472 + 243 WP_003403210.1 hypothetical protein -
BCG_RS03385 741667..741894 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
BCG_RS03390 741891..742292 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
BCG_RS22205 742421..742504 + 84 Protein_673 galactose-1-phosphate uridylyltransferase -
BCG_RS03395 742523..743605 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
BCG_RS03400 743602..744693 + 1092 WP_003403225.1 galactokinase -
BCG_RS03410 745088..746245 + 1158 WP_003903091.1 hypothetical protein -
BCG_RS03415 746256..747203 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T21853 WP_003403218.1 NC_008769:741891-742292 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T21853 NC_008769:741891-742292 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT21853 WP_003403213.1 NC_008769:741667-741894 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT21853 NC_008769:741667-741894 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References