Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 114119..114624 Replicon chromosome
Accession NZ_CP084413
Organism Pseudomonas sp. HS-18

Toxin (Protein)


Gene name parE Uniprot ID A0A1B8TFU7
Locus tag LDJ84_RS00510 Protein ID WP_024763697.1
Coordinates 114119..114400 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B8V0Q7
Locus tag LDJ84_RS00515 Protein ID WP_024763698.1
Coordinates 114397..114624 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDJ84_RS00485 (LDJ84_00485) 110020..110970 + 951 WP_226045741.1 alpha/beta hydrolase -
LDJ84_RS00490 (LDJ84_00490) 111044..112072 + 1029 WP_065327708.1 AraC family transcriptional regulator -
LDJ84_RS00495 (LDJ84_00495) 112074..112529 - 456 WP_024763694.1 GNAT family N-acetyltransferase -
LDJ84_RS00500 (LDJ84_00500) 112573..113490 - 918 WP_024763695.1 LysR family transcriptional regulator -
LDJ84_RS00505 (LDJ84_00505) 113588..113875 + 288 WP_024763696.1 DUF2218 domain-containing protein -
LDJ84_RS00510 (LDJ84_00510) 114119..114400 - 282 WP_024763697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDJ84_RS00515 (LDJ84_00515) 114397..114624 - 228 WP_024763698.1 CopG family ribbon-helix-helix protein Antitoxin
LDJ84_RS00520 (LDJ84_00520) 114865..116250 + 1386 WP_038803461.1 sodium:solute symporter -
LDJ84_RS00525 (LDJ84_00525) 116278..117234 + 957 WP_024763699.1 agmatinase -
LDJ84_RS00530 (LDJ84_00530) 117310..118236 + 927 WP_037011732.1 LysR family transcriptional regulator -
LDJ84_RS00535 (LDJ84_00535) 118233..118946 + 714 WP_084358451.1 phytanoyl-CoA dioxygenase family protein -
LDJ84_RS00540 (LDJ84_00540) 118962..119363 + 402 WP_024763702.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10323.76 Da        Isoelectric Point: 5.6558

>T218528 WP_024763697.1 NZ_CP084413:c114400-114119 [Pseudomonas sp. HS-18]
MSLQWTHKAAADLDAIYDHYVVLIGPEKALRAIQDIVEQVSPLANLDLSSSGVPSEVPGVRELSVERWPYQAAFRVKGRS
VQILRIDRVDNPG

Download         Length: 282 bp

>T218528 NZ_CP116035:c630141-629677 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8245.19 Da        Isoelectric Point: 5.9478

>AT218528 WP_024763698.1 NZ_CP084413:c114624-114397 [Pseudomonas sp. HS-18]
VTTVVSFRADDSLVAALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGVADADAGHLLEHAAIEGKWGLA

Download         Length: 228 bp

>AT218528 NZ_CP116035:c630476-630141 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B8TFU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B8V0Q7

References