Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 529327..529985 Replicon chromosome
Accession NZ_CP084406
Organism Sphingobium sp. CFD-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LDB29_RS22645 Protein ID WP_257541695.1
Coordinates 529578..529985 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LDB29_RS22640 Protein ID WP_257541693.1
Coordinates 529327..529581 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB29_RS22625 524985..526652 - 1668 WP_257557993.1 thiamine pyrophosphate-binding protein -
LDB29_RS22630 526645..527391 - 747 WP_257557995.1 cyclase family protein -
LDB29_RS22635 527413..528903 - 1491 WP_257557997.1 aldehyde dehydrogenase -
LDB29_RS22640 529327..529581 + 255 WP_257541693.1 plasmid stabilization protein Antitoxin
LDB29_RS22645 529578..529985 + 408 WP_257541695.1 type II toxin-antitoxin system VapC family toxin Toxin
LDB29_RS22650 530041..530331 + 291 WP_257541697.1 putative quinol monooxygenase -
LDB29_RS22655 531057..532511 + 1455 WP_218036328.1 IS21 family transposase -
LDB29_RS22660 532508..533275 + 768 WP_054944222.1 IS21-like element helper ATPase IstB -
LDB29_RS22665 533421..534392 + 972 WP_257557999.1 diiron oxygenase -
LDB29_RS22670 534411..534602 + 192 WP_257541700.1 rubredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 478112..584891 106779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14292.40 Da        Isoelectric Point: 5.1071

>T218523 WP_257541695.1 NZ_CP084406:529578-529985 [Sphingobium sp. CFD-2]
MIVLDTNVVSEAMKPEPAPAVRDWLDEQAAETLYLSSITVAELLFGIAVLPDGRRKQKLAATLDGMLDLFDGRILPFDTS
AARHYADLAVSARKAGKGFPTPNGYIAAIATVHGFAVATRDDSAFVAAGVAVIHP

Download         Length: 408 bp

>T218523 NZ_CP116024:19305-19457 [Enterococcus faecium]
ATTGAAAAAAATGGCTGGGTTGAGCGAAGGCAAGAGGGATTTCATCATCATCTTTATAAGGATGGTGTTAGAATCACTGT
TCCTGTTCATGCCAATCAAGATCTTGGCCGAGGACTTGAGCGAAAAATTTTAAAGGATGCGGGATTGAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9192.43 Da        Isoelectric Point: 10.9254

>AT218523 WP_257541693.1 NZ_CP084406:529327-529581 [Sphingobium sp. CFD-2]
MPAVTIRNLSDETHRALKVRAAHHGRSAEAEMRDILEAAVRPANRLRIGSALSALSRDAGLTNADFEALEQGRDRTPAKP
MSFK

Download         Length: 255 bp

>AT218523 NZ_CP116024:19491-19922 [Enterococcus faecium]
ATGTTAAGTGAGCCTTTAGCAAAAACCTATCCTGCTATTTTTAGCCCAGAAGAAGGTGGTGGGTACTTTATTGAATTTCC
TGATGTTCAAGGTGCTTACACAGGAATTAACGAAGACGATATATCTTATGGAATTGCTATGGCACAAGAGGTGTTAGGTA
TGGTTTTAGCAGATTATATTGAGCATGAAGATCTACTTCCAGAACCAACACCAATCAATAAGATTACTGTTGAAGATGAT
TCTTTTACTACTTTAATTCGTGTAGATGTTGCCAAATATTTGAAAGACACAGAACTTGTCAAAAAAACCTTAACAATTCC
TCAATGGGCGGATAAGCTAGGCAAAAGGGCTGGCATAAATTTTTCAGTCCTTCTAACAGAATCAATTGCAGATAAAGCAG
ATAACATTCTTCGTTCTGGAAGAAATAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References