Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3534107..3534717 Replicon chromosome
Accession NZ_CP084405
Organism Sphingobium sp. CFD-2

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LDB29_RS17485 Protein ID WP_137710086.1
Coordinates 3534107..3534397 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LDB29_RS17490 Protein ID WP_137710087.1
Coordinates 3534430..3534717 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB29_RS17475 3530817..3531833 + 1017 WP_257555040.1 NADP-dependent oxidoreductase -
LDB29_RS17480 3531902..3532765 - 864 WP_025547899.1 OmpA family protein -
LDB29_RS17485 3534107..3534397 + 291 WP_137710086.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDB29_RS17490 3534430..3534717 + 288 WP_137710087.1 putative addiction module antidote protein Antitoxin
LDB29_RS17495 3534766..3535845 - 1080 WP_257555044.1 IS110 family transposase -
LDB29_RS17500 3536613..3537071 + 459 WP_137710092.1 DUF2059 domain-containing protein -
LDB29_RS17505 3537195..3537584 - 390 WP_048578749.1 hypothetical protein -
LDB29_RS17510 3537687..3537845 - 159 WP_137710093.1 SpoIIIAH-like family protein -
LDB29_RS17515 3537936..3538979 - 1044 WP_257555050.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3534107..3576517 42410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10647.19 Da        Isoelectric Point: 10.0413

>T218522 WP_137710086.1 NZ_CP084405:3534107-3534397 [Sphingobium sp. CFD-2]
METQQTPAFADWFESLRDRKAKSKIAGRIARIELGLMGDVKSVGDGVSEARIDFGPGYRLYFTRRGEQLIILLVGGDKSS
QQRDIAKAKEMAAQIS

Download         Length: 291 bp

>T218522 NZ_CP116023:499782-500123 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTTCACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 5.6939

>AT218522 WP_137710087.1 NZ_CP084405:3534430-3534717 [Sphingobium sp. CFD-2]
MAIKLTRFDAAEYLTEPEDQAELLADALTTGDVHVIAKAIGIVARAHGMTELSKETGIKRQQLYRALGPDGNPTLETMLK
VLPALGLRMRIEAAA

Download         Length: 288 bp

>AT218522 NZ_CP116023:499552-499782 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References