Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1724758..1725416 Replicon chromosome
Accession NZ_CP084398
Organism Sphingobium sp. CFD-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LDB26_RS08775 Protein ID WP_257541695.1
Coordinates 1725009..1725416 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LDB26_RS08770 Protein ID WP_257541693.1
Coordinates 1724758..1725012 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB26_RS08750 1720898..1721407 - 510 WP_257541687.1 hypothetical protein -
LDB26_RS08755 1722002..1722931 - 930 WP_257542029.1 nucleotidyltransferase and HEPN domain-containing protein -
LDB26_RS08760 1722984..1723232 - 249 WP_257541689.1 sigma factor-like helix-turn-helix DNA-binding protein -
LDB26_RS08765 1723229..1724329 - 1101 WP_257541691.1 tyrosine-type recombinase/integrase -
LDB26_RS08770 1724758..1725012 + 255 WP_257541693.1 plasmid stabilization protein Antitoxin
LDB26_RS08775 1725009..1725416 + 408 WP_257541695.1 type II toxin-antitoxin system VapC family toxin Toxin
LDB26_RS08780 1725472..1725762 + 291 WP_257541697.1 putative quinol monooxygenase -
LDB26_RS08785 1726403..1727311 + 909 WP_257542031.1 diiron oxygenase -
LDB26_RS08790 1727330..1727521 + 192 WP_257541700.1 rubredoxin -
LDB26_RS08795 1727578..1728891 - 1314 WP_257541702.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
LDB26_RS08800 1729072..1729821 + 750 WP_257541704.1 glutamine amidotransferase -
LDB26_RS08805 1729859..1730095 + 237 Protein_1730 serine hydroxymethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1673111..1759236 86125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14292.40 Da        Isoelectric Point: 5.1071

>T218513 WP_257541695.1 NZ_CP084398:1725009-1725416 [Sphingobium sp. CFD-1]
MIVLDTNVVSEAMKPEPAPAVRDWLDEQAAETLYLSSITVAELLFGIAVLPDGRRKQKLAATLDGMLDLFDGRILPFDTS
AARHYADLAVSARKAGKGFPTPNGYIAAIATVHGFAVATRDDSAFVAAGVAVIHP

Download         Length: 408 bp

>T218513 NZ_CP116012:c2374070-2373894 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9192.43 Da        Isoelectric Point: 10.9254

>AT218513 WP_257541693.1 NZ_CP084398:1724758-1725012 [Sphingobium sp. CFD-1]
MPAVTIRNLSDETHRALKVRAAHHGRSAEAEMRDILEAAVRPANRLRIGSALSALSRDAGLTNADFEALEQGRDRTPAKP
MSFK

Download         Length: 255 bp

>AT218513 NZ_CP116012:2373853-2373953 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References