Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/ElaA-DUF1778
Location 944995..945834 Replicon chromosome
Accession NZ_CP084398
Organism Sphingobium sp. CFD-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A0S3EYY3
Locus tag LDB26_RS04875 Protein ID WP_062064438.1
Coordinates 944995..945510 (-) Length 172 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A0S3EYZ1
Locus tag LDB26_RS04880 Protein ID WP_062064445.1
Coordinates 945526..945834 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDB26_RS04845 940390..940968 + 579 WP_062064427.1 S26 family signal peptidase -
LDB26_RS04850 940949..941296 + 348 WP_062064429.1 DUF736 domain-containing protein -
LDB26_RS04855 941332..941676 + 345 WP_062064431.1 DUF736 domain-containing protein -
LDB26_RS04860 941681..942388 + 708 WP_062064433.1 lytic transglycosylase domain-containing protein -
LDB26_RS04865 942385..942966 + 582 WP_062064435.1 hypothetical protein -
LDB26_RS04870 943205..944980 + 1776 WP_062064436.1 DUF3363 domain-containing protein -
LDB26_RS04875 944995..945510 - 516 WP_062064438.1 GNAT family N-acetyltransferase Toxin
LDB26_RS04880 945526..945834 - 309 WP_062064445.1 DUF1778 domain-containing protein Antitoxin
LDB26_RS04885 945917..947902 + 1986 WP_062064447.1 conjugal transfer protein TraG -
LDB26_RS04890 947911..948333 + 423 WP_062064448.1 CopG family transcriptional regulator -
LDB26_RS04895 948447..948704 + 258 WP_257541981.1 type II toxin-antitoxin system ParD family antitoxin -
LDB26_RS04900 948774..949139 - 366 WP_062064450.1 hypothetical protein -
LDB26_RS04905 949392..950378 + 987 WP_062064452.1 P-type conjugative transfer ATPase TrbB -
LDB26_RS04910 950375..950707 + 333 WP_062064454.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 868334..949139 80805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(48-150)

Antitoxin

Vibrio phage ICP1, Orf50

(14-101)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 18179.96 Da        Isoelectric Point: 8.5126

>T218511 WP_062064438.1 NZ_CP084398:c945510-944995 [Sphingobium sp. CFD-1]
VADIRITPPARLTADHDVAGFANGVHASLDDWLRDRALASEGSSARTYVVCNAAEPRRVVGYYTITTAMEQRAALPSAKL
RRGMPDRVPLLLIGRLAVDAGFQGIGLGADLLADALRRCAAAAEIAGARAVIVHAIDEKAAAFYARHGFIPTSLGELVML
LPIEAIRSRPN

Download         Length: 516 bp

>T218511 NZ_CP116011:c1220555-1219809 [Bacillus amyloliquefaciens]
ATGCTTTTGTTTTATCAAATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTATGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGGCAATACTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGAGGGAAATATTGGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCAGAAGGCATCAGCAGACTGCTGGCCGCTTATGCAGAAAAAATGAATGTCACGGCTTCATTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACAGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGCCTTAA
CCGGAAAGACGTCTACTATGATCAAAAAGGAAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCAGTATGTGATCA
AACTCACGTCAGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11431.07 Da        Isoelectric Point: 8.8725

>AT218511 WP_062064445.1 NZ_CP084398:c945834-945526 [Sphingobium sp. CFD-1]
MAQTTPAHPNGRASARKDDVIQIRASAGMKAILTRAAALRGQKLSEFMLDSARREAEDAILDQRTFFLDAEQHEQFLAML
DAPPAPSDALQTLMRRKPIWER

Download         Length: 309 bp

>AT218511 NZ_CP116011:c1219809-1219639 [Bacillus amyloliquefaciens]
ATGGAGCAGGCGTTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGCTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCACACCGCCAGAATTTTCAAAGAAAATGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3EYY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3EYZ1

References