Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4841193..4841709 Replicon chromosome
Accession NZ_CP084397
Organism Klebsiella pneumoniae subsp. pneumoniae strain MRSN752019

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KF608_RS26360 Protein ID WP_009486548.1
Coordinates 4841193..4841477 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KF608_RS26365 Protein ID WP_002886901.1
Coordinates 4841467..4841709 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF608_RS26335 (4836610) 4836610..4836873 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KF608_RS26340 (4837003) 4837003..4837176 + 174 WP_032433782.1 hypothetical protein -
KF608_RS26345 (4837179) 4837179..4837922 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KF608_RS26350 (4838279) 4838279..4840417 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KF608_RS26355 (4840725) 4840725..4841189 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KF608_RS26360 (4841193) 4841193..4841477 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF608_RS26365 (4841467) 4841467..4841709 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KF608_RS26370 (4841787) 4841787..4843697 - 1911 WP_009486549.1 PRD domain-containing protein -
KF608_RS26375 (4843720) 4843720..4844874 - 1155 WP_002886900.1 lactonase family protein -
KF608_RS26380 (4844941) 4844941..4845681 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T218507 WP_009486548.1 NZ_CP084397:c4841477-4841193 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T218507 NZ_CP116007:c1371421-1370771 [Pseudoxanthomonas mexicana]
ATGGCTAACCACTACCCGAACCTCAACCCGGAGAAGGCGCTGATCTGGCGCATCGTCCACCGCGACAACTTGTCGTGGAT
TCTGGATAATGGTCTGCACTGTGGCAACGGCGGTATGCAGGCTCCGGGTTGGGTGAGCATCGGCAACCCTGAACTGATCG
ACAAGCGCGCCAGTCATCCTGTGCCACTGCCGCCCGGTGGTTTCCTGAATGACTACGTGCCGTTCTACTTCACCCCGTTT
TCGCCAATGCTGCGCAACATCCATACTGGTTGGGGCGGCATTCAGCGGAGGCCCAACGAGGAGATCGTAATCCTTGTTTC
CAGCCTGCATCACGTCGCAGCACAGGGGTGGCCGTTCCTGTTCACCGACAGCCACGCCTACTACCAGTGGGCAAACTTCT
ATTCGGATTTGGCGGGTGTCGACAAGATCGACTGGCCGCTGCTTCAGGCACGGGATTTCCGGCGCGATCCGGAAGACCCT
GCCAAGTTCGAGCGATATCAAGCCGAGGCGCTGATTCACCGACACTTGCCGATCAATGGCTTACTCGGTGTTGTGTGTTA
TACGGATAATTTGAGGCAAGTCATCGAGCAGCAGATTCAAGCACGCAACTTGAATCTACCAGTCTATGCCCGCACGGGGT
GGTATTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT218507 WP_002886901.1 NZ_CP084397:c4841709-4841467 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT218507 NZ_CP116007:c1370771-1369704 [Pseudoxanthomonas mexicana]
ATGATCACATTTACTCAAGGCAACCTTCTTGAAGCCCGCGCCGAGGCGCTGGTCAACACCGTCAACACGGTGGGTGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTTGCCGACAACTTCCGCCGCTACGCAGTCGCGTGCAAGGCCAAGG
AAGTACGCACCGGCAAGATGTTCGTCACCGAGGTGAACGAACTGGACGGCCCGCGCTGGATCGTCAACTTCCCGACCAAA
CAGCACTGGCGTGGCGATTCGAAGATCGAGTGGATCACCGATGGGCTTCAAGACCTGCGCCGCTTCCTGATCGAGAATAA
GGTCAAATCCATCGCCATCCCGCCCCTGGGTGCGGGCAACGGCGGGCTGGACTGGGCCGAGGTACGCCCGCAGATCGAAG
ATGCGCTGGCTGGCCTCGACACCGAAATCCTGGTGTTCGAGCCAACCCAGAAGTACCAGAACGTCGCCAAGCGCACGGGC
GTGGAGAAGCTGACCCCGGCCCGCGCCCTGATTGCCGAACTGGTGCGTCGCTACTGGGTATTGGGCATGGAATGCAGTTT
GCTCGAAATCCAGAAGTTGGCGTGGTTCCTTGAACGCTCCATCGAGCGCACGAGTCTGACTCCGCTGGATTTGCGCTTTG
TGCCGCACAAGTACGGCCCCTACGCCGACCGCTTGCGGCACCTACTGGAGGGACTGGATGGCAGTTACCTCCACTGCGAC
AAGCGCATCGGCGACGCTGATCCGCTGGACGTGATCTGGTTCGACGACGGACGCAAGACCTTCGTCCAGACCTATCTCAA
GAGCGAAGCCAAAGACTATGTCCCGGCGCTGGAAGCCACGGCAGCGCTGATCGACGGCTTCGAGTCGCCCTACGGCATGG
AACTGCTGTCCACGGTGGACTGGCTGCTGTCGCAGGAAGGCGTCGCCCCGACGGTGCCCGCCGTGCGCGAGGGGCTGCAC
CATTGGCGCGGTGGCCCGGGTGCAGCGGCCCGCAAGGACAGACTCTTTGACGACCGGGCTCTGAGCATCGCGCTGGAGCG
GCTGGCATCGAGTACGGTGGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References