Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4103372..4103991 | Replicon | chromosome |
Accession | NZ_CP084397 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain MRSN752019 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | KF608_RS22895 | Protein ID | WP_002892050.1 |
Coordinates | 4103773..4103991 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | KF608_RS22890 | Protein ID | WP_002892066.1 |
Coordinates | 4103372..4103746 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KF608_RS22880 (4098524) | 4098524..4099717 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
KF608_RS22885 (4099740) | 4099740..4102886 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
KF608_RS22890 (4103372) | 4103372..4103746 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
KF608_RS22895 (4103773) | 4103773..4103991 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
KF608_RS22900 (4104154) | 4104154..4104720 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
KF608_RS22905 (4104692) | 4104692..4104832 | - | 141 | WP_004147370.1 | hypothetical protein | - |
KF608_RS22910 (4104853) | 4104853..4105323 | + | 471 | WP_020802585.1 | YlaC family protein | - |
KF608_RS22915 (4105298) | 4105298..4106749 | - | 1452 | WP_004183206.1 | PLP-dependent aminotransferase family protein | - |
KF608_RS22920 (4106850) | 4106850..4107548 | + | 699 | WP_023287311.1 | GNAT family protein | - |
KF608_RS22925 (4107545) | 4107545..4107685 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
KF608_RS22930 (4107685) | 4107685..4107948 | - | 264 | WP_032432663.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T218505 WP_002892050.1 NZ_CP084397:4103773-4103991 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T218505 NZ_CP116006:2867278-2867454 [Achromobacter mucicolens]
GTGAAGCAAAGCGAGTTCAAACGGTGGCTCGCTTCCAAAGGAGTGACTTTCGCAGAGGGTAGCAACCACACGAAAGCCTA
CTACAACGGAAAACAGACCACCCTGCCTAGGCACCCTTCCAAGGAATTGAGAGACGGCACTAGGCAGAACATCCTGAAGA
AACTAGGACTGAAATAG
GTGAAGCAAAGCGAGTTCAAACGGTGGCTCGCTTCCAAAGGAGTGACTTTCGCAGAGGGTAGCAACCACACGAAAGCCTA
CTACAACGGAAAACAGACCACCCTGCCTAGGCACCCTTCCAAGGAATTGAGAGACGGCACTAGGCAGAACATCCTGAAGA
AACTAGGACTGAAATAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT218505 WP_002892066.1 NZ_CP084397:4103372-4103746 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT218505 NZ_CP116006:2867511-2867933 [Achromobacter mucicolens]
ATGGCTCGATATCCTGCATTTCTCGACCCCGAGGGCGACGGCTTCAACGTTACGTTCCGTGATATCCCGGAGGCGATCAC
CTGCGGCGACAACCGCGATGACGCGCTGGAAATGGCCGCCGGCGCTCTGGTGACTGCCATGGAGTTCTATTTTGAGGACC
GTCGGCCCGTCCCTCTTCCGTCCGATCCCAAAGATGGAGAGGTTCTTATCGCCCTTCCCGCGAGCGTATGGGCGAAGGTT
CTATTGCTGAACGAGATGATCGCTCAGCGTGTCACGCCTGCAGAGTTGGCCCGCAGGTTGAACACACGCCCGCAAGAGGT
GACCCGCATCATAAATCTGGGTCATGCCACGAAGATCGACACCATCGCGGCGGCCTTGCGCACGATGGGAAAGGATCTCG
AGATTTCCGTCCGACAAGCCTAG
ATGGCTCGATATCCTGCATTTCTCGACCCCGAGGGCGACGGCTTCAACGTTACGTTCCGTGATATCCCGGAGGCGATCAC
CTGCGGCGACAACCGCGATGACGCGCTGGAAATGGCCGCCGGCGCTCTGGTGACTGCCATGGAGTTCTATTTTGAGGACC
GTCGGCCCGTCCCTCTTCCGTCCGATCCCAAAGATGGAGAGGTTCTTATCGCCCTTCCCGCGAGCGTATGGGCGAAGGTT
CTATTGCTGAACGAGATGATCGCTCAGCGTGTCACGCCTGCAGAGTTGGCCCGCAGGTTGAACACACGCCCGCAAGAGGT
GACCCGCATCATAAATCTGGGTCATGCCACGAAGATCGACACCATCGCGGCGGCCTTGCGCACGATGGGAAAGGATCTCG
AGATTTCCGTCCGACAAGCCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |