Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1452183..1452826 Replicon chromosome
Accession NZ_CP084397
Organism Klebsiella pneumoniae subsp. pneumoniae strain MRSN752019

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag KF608_RS09785 Protein ID WP_032433387.1
Coordinates 1452410..1452826 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag KF608_RS09780 Protein ID WP_001261276.1
Coordinates 1452183..1452413 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF608_RS09765 (1447205) 1447205..1448292 + 1088 Protein_1396 transcriptional regulator -
KF608_RS09770 (1448295) 1448295..1450535 + 2241 WP_045326788.1 P-loop NTPase fold protein -
KF608_RS09775 (1451063) 1451063..1451878 - 816 WP_032433388.1 hypothetical protein -
KF608_RS09780 (1452183) 1452183..1452413 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KF608_RS09785 (1452410) 1452410..1452826 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
KF608_RS09790 (1452982) 1452982..1453962 + 981 WP_032433385.1 hypothetical protein -
KF608_RS09795 (1454157) 1454157..1455728 - 1572 WP_032433383.1 AAA family ATPase -
KF608_RS09800 (1456047) 1456047..1456295 + 249 WP_032433382.1 hypothetical protein -
KF608_RS09805 (1456354) 1456354..1456872 + 519 WP_045326794.1 hypothetical protein -
KF608_RS09810 (1456903) 1456903..1457394 + 492 WP_032433378.1 hypothetical protein -
KF608_RS09815 (1457454) 1457454..1457657 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1436819..1482836 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T218494 WP_032433387.1 NZ_CP084397:1452410-1452826 [Klebsiella pneumoniae subsp. pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T218494 NZ_CP116003:c3299829-3299173 [Edwardsiella piscicida]
ATGGCTTATGACTACAGCGCCAGTCTCAACCCGCAAAAAGCCCTGATCTGGCGCATTGTCCATCGGGATAATATCCCGTG
GATACTGGACAACGGCTTGCACTGCGGCAACAGTCAAGTGCAGGCGGTAAACTGGATCAATATCGGCAACCCGGAACTTA
TCGGCAAACGCGCCGGGCATCCGGTGCCTGTCGGGACGGGCGGGACGCTGCATGACTACGTGCCGTTTTACTTTACCCCC
TTTTCGCCGATGCTGATGAATATCCACAGCGGGCGTGGCGGCATTACGCAGCGCCCCAACGAGGAAATCGTCATTCTGGT
CAGCAGCCTGCGAAGCGTGGCGGCGCAAAACGCCCCCTTCGTGTTTACCGACAGCCATGCCTACTATAACTGGGCCAACT
ACTACACCCGCCTGGAGGACCTGAACCAGATCGACTGGTCTATCTTACAGGCGCGGGATTTCCGTCGCGATCCGGACGAT
CCGGCGAAGTTTGAACGCTATCAGGCCGAGGCGTTAATCTGGCAGCACTGCCCCATCACACTGCTGGTCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGCTGTCGCAACGTAATCTGACAATGCCCGTTCACGCACGGGCCG
GGTGGTACTTCTCATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT218494 WP_001261276.1 NZ_CP084397:1452183-1452413 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT218494 NZ_CP116003:c3299176-3298109 [Edwardsiella piscicida]
ATGATCACATATACACAAGGCAATTTACTGGACGCGCCCGTGGAAGCACTGGTGAATACGGTGAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTTAAAGAGCGCTTCCCCGACAATATGAAAGCCTATGCCCACGCCTGCAAACAAAAGC
AGGTGATGACCGGCAAGATGTTTATTACCGAAACCGGCGAGTTGATGGGGCCGCGCTGGATCGTCAACTTCCCTACCAAG
CAGCACTGGCGCGCCGACTCTCGCATGGCGTGGATCGAGGACGGCTTGCAGGACCTGCGCCGCTTTTTGATCGAAAAGAA
AGTGCGGTCCATCGCCATTCCCCCGCTGGGCGCGGGCAACGGCGGCCTGAACTGGCCGGACGTCCGGGCGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATCCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCAGC
GGTGTAAAAAAGCTCACTCCCGCCAGAGCGATGATCGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCGTGGCTGCTACAACGCGCCATTGAACTGCACCAGCAGGAGGACGTGCTAAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTATGCTCCTAACCTGAACCATCTGCTTAACGCGCTGGACGGTACCTATCTGAAA
GCCGAAAAGCGTATCCCGGACAGCCAGCCACTGGATGTGATCTGGTTTAACGATCGGGAAAAAGAACACATCAACCTATG
GCTGAACAGCGAAGCCAAAGCGTGGTTGCCAGCGCTTGAGCAGGTCAGCCAGTTGATTGACGGTTTTGAATCGCCGTTTG
GTCTGGAGCTGTTGGCGACCGTTGACTGGTTGTTGACCCGGGGACAATGCCAGCCCACGCTGGACTCCGTGAAAGAGGGG
TTGCATCAGTGGCCTGCGGGAGAACCTTGGGCCAGCCGTAAGATAAAGCTGTTTGACGATAAGAATCTGCAATTCGCCAT
TAACCGCGTGATGGAGTTTCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References