Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 155200..155870 | Replicon | plasmid pSI646A-ARMA-Vir-NDM |
| Accession | NZ_CP084395 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain MRSN752019 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | KF608_RS01460 | Protein ID | WP_004213072.1 |
| Coordinates | 155200..155643 (-) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | KF608_RS01465 | Protein ID | WP_004213073.1 |
| Coordinates | 155640..155870 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KF608_RS01425 (KF608_01425) | 150607..150882 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
| KF608_RS01430 (KF608_01430) | 150945..151436 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| KF608_RS01435 (KF608_01435) | 151485..152405 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| KF608_RS01440 (KF608_01440) | 152496..152899 | + | 404 | Protein_172 | GAF domain-containing protein | - |
| KF608_RS01445 (KF608_01445) | 153418..154056 | - | 639 | Protein_173 | mucoid phenotype regulator RmpA2 | - |
| KF608_RS01450 (KF608_01450) | 154473..154777 | + | 305 | Protein_174 | transposase | - |
| KF608_RS01455 (KF608_01455) | 154800..155051 | - | 252 | WP_186987481.1 | hypothetical protein | - |
| KF608_RS01460 (KF608_01460) | 155200..155643 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KF608_RS01465 (KF608_01465) | 155640..155870 | - | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KF608_RS01470 (KF608_01470) | 156478..157611 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| KF608_RS01475 (KF608_01475) | 157627..157920 | + | 294 | WP_004213076.1 | hypothetical protein | - |
| KF608_RS01480 (KF608_01480) | 157910..158116 | - | 207 | WP_004213077.1 | hypothetical protein | - |
| KF608_RS01485 (KF608_01485) | 158468..158758 | + | 291 | WP_004213078.1 | hypothetical protein | - |
| KF608_RS01490 (KF608_01490) | 158748..159647 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / mph(A) / sul1 / qacE / dfrA5 / mph(E) / msr(E) / armA / sul2 / blaNDM-1 / aph(3')-VI / qnrS1 / blaCTX-M-15 | rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..374716 | 374716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T218489 WP_004213072.1 NZ_CP084395:c155643-155200 [Klebsiella pneumoniae subsp. pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T218489 NZ_CP116003:c1092519-1092316 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT218489 WP_004213073.1 NZ_CP084395:c155870-155640 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT218489 NZ_CP116003:c1092908-1092540 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|