Detailed information of TA system TA218487

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1674449..1675091
• Replicon: chromosome
• Accession: NZ_CP084392
• Organism: Pseudochrobactrum sp. XF203

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LDL70_RS07475
• Protein ID: WP_225688172.1
• Coordinates: 1674449..1674631 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LDL70_RS07480
• Protein ID: WP_225688174.1
• Coordinates: 1674693..1675091 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDL70_RS07450 (LDL70_07450)	1669597..1670052	-	456	WP_225688162.1	hypothetical protein	-
LDL70_RS07455 (LDL70_07455)	1670055..1671167	-	1113	WP_225688164.1	hypothetical protein	-
LDL70_RS07460 (LDL70_07460)	1671170..1672477	-	1308	WP_225688166.1	DUF1073 domain-containing protein	-
LDL70_RS07465 (LDL70_07465)	1672543..1673937	-	1395	WP_225688168.1	PBSX family phage terminase large subunit	-
LDL70_RS07470 (LDL70_07470)	1673897..1674301	-	405	WP_225688170.1	terminase small subunit	-
LDL70_RS07475 (LDL70_07475)	1674449..1674631	+	183	WP_225688172.1	type II toxin-antitoxin system HicA family toxin	Toxin
LDL70_RS07480 (LDL70_07480)	1674693..1675091	+	399	WP_225688174.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LDL70_RS07485 (LDL70_07485)	1675259..1675459	+	201	WP_225688176.1	hypothetical protein	-
LDL70_RS07490 (LDL70_07490)	1675677..1676057	+	381	WP_225688178.1	hypothetical protein	-
LDL70_RS07495 (LDL70_07495)	1676266..1676580	+	315	WP_225688180.1	hypothetical protein	-
LDL70_RS07500 (LDL70_07500)	1676671..1677693	-	1023	WP_225688182.1	DUF2806 domain-containing protein	-
LDL70_RS07505 (LDL70_07505)	1677925..1678524	-	600	WP_225688184.1	hypothetical protein	-
LDL70_RS07510 (LDL70_07510)	1678535..1678798	-	264	WP_225688186.1	DUF2312 domain-containing protein	-
LDL70_RS07515 (LDL70_07515)	1678841..1679743	-	903	WP_225688188.1	DUF1376 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1647096..1698710	51614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-124)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6765.99 Da
• Isoelectric Point: 10.7901

>T218487 WP_225688172.1 NZ_CP084392:1674449-1674631 [Pseudochrobactrum sp. XF203]
MLRDSKKIVKRLENEGFELVSVKGSHHKFRKGDMTIIVPHPKKDLPIGTAKAIAKQAGWE

Nucleotide

• Length: 183 bp

>T218487 NZ_CP115994:c71906-71565 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGTTGGAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACAATGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCCACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGATTTTACAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14437.05 Da
• Isoelectric Point: 4.2996

>AT218487 WP_225688174.1 NZ_CP084392:1674693-1675091 [Pseudochrobactrum sp. XF203]
MKHFFALVHKDSDSAYGIQFPDLPSVFSASDEAEDIVKNAIEALQLYAEDETLPEASSHADIVARDDVRSALNDGAYLIS
VPYIEDDSAVVRVNVTFERGVLKAIDNVAKDRGLTRSSFLAQAARHEIEVGV

Nucleotide

• Length: 399 bp

>AT218487 NZ_CP115994:c72136-71906 [Enterococcus faecalis]
ATGTTAACAACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGATCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA