Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1740899..1741476 Replicon chromosome
Accession NZ_CP084384
Organism Lactobacillus helsingborgensis strain IBH003

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LDX52_RS08345 Protein ID WP_267271220.1
Coordinates 1741144..1741476 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LDX52_RS08340 Protein ID WP_109918859.1
Coordinates 1740899..1741150 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDX52_RS08330 (LDX52_08325) 1738425..1739354 - 930 WP_267271219.1 cytochrome C5 -
LDX52_RS08335 (LDX52_08330) 1739504..1740742 + 1239 WP_199283089.1 MFS transporter -
LDX52_RS08340 (LDX52_08335) 1740899..1741150 + 252 WP_109918859.1 hypothetical protein Antitoxin
LDX52_RS08345 (LDX52_08340) 1741144..1741476 + 333 WP_267271220.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LDX52_RS08350 1741563..1741694 + 132 WP_255409548.1 hypothetical protein -
LDX52_RS08355 (LDX52_08345) 1741759..1742661 - 903 WP_267271221.1 LysR family transcriptional regulator -
LDX52_RS08360 (LDX52_08350) 1742767..1744008 + 1242 WP_267271222.1 MFS transporter -
LDX52_RS08365 (LDX52_08355) 1744013..1745452 + 1440 WP_267271223.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12758.84 Da        Isoelectric Point: 8.3342

>T218483 WP_267271220.1 NZ_CP084384:1741144-1741476 [Lactobacillus helsingborgensis]
MVIKQGSILLMDLSPKQGHEQSGKQPYLYLSYNGVEKYAHIAVFAPISTTKRRYPLYQELPAVSQTKGVVMLDQLVTIDY
HNQPFHYLEQLPDDYMEKILKIVKVVFQKD

Download         Length: 333 bp

>T218483 NZ_CP115992:2491410-2491526 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGCATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9591.75 Da        Isoelectric Point: 4.4992

>AT218483 WP_109918859.1 NZ_CP084384:1740899-1741150 [Lactobacillus helsingborgensis]
MIRATISKWGNSKGIRLNQAVLQALNATIGDQLNFKIEDNKVIMSKQDDSPDLTFEELFKDYSGEEFDTEIKLPDERKGN
ERW

Download         Length: 252 bp

>AT218483 NZ_CP115992:c2491642-2491437 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATGC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References